A bioassay for the possible carcinogenicity of N-(1-naphthyl)ethylenediamine dihydrochloride was conducted using Fischer 344 rats and B6C3F1 mice. N-(1-Naphthyl)ethylenediamine dihydrochloride was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty-five rats of each sex and 50 mice of each sex were placed on test as contr...

Abstract Background Quinolones and cephalosporins are antibiotic agents with activity against Gram-positive Gram-negative bacteria. They contain chromophores amine groups which electron-rich centres capable of donating electrons to electron-deficient compounds. A survey the literature revealed that 2, 4-dinitro-1-naphthol, a nitroaromatic useful in chemical synthesis, can accept charge transfer...

Since the ultimate carcinogen W-hydroxy-1-naphthylamine (N-HO-1-NA) reacts selectively with DMA at the O6 atom of the guanine base, an investigation of the consequences of this potentially mispairing lesion upon DMA structure was under taken. Fluorescence spectroscopic studies, which detected only the major N-HO-1-NA-O6-guanine adduct, showed that the fluorescence decay rate for the naphthyl re...