considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. as a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different a...

Aerobic respiration of Streptococcus pyogenes and pneumococcus Type 1 are strongly inhibited by KCN, NaN(3), and Na(2)S. The anaerobic glycolysis of glucose by pneumococcus is also inhibited by KCN and NaN(3). Streptococcus pyogenes, E. coli, pneumococcus Type 1, B. subtilis, B. proteus, and Staphylococcus aureus did not catalyze the oxygen uptake by p-phenylenediamine in the presence of added ...

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1), which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2''-merca...

Stevenson, Dobriner, and Rhoads (5) reported that p-dimethylaminoazobenzene when fed to rats is decomposed and metabolized to several simpler compounds. One of these split products, N,N-dimethylp-phenylenediamine, has been found by us ( i ) to be toxic to the glandular epithelium of the rat liver at concentrations of o.oooI M, while equivalent effects on the ductal epithelium were produced only...

1. Tightly coupled mitochondria were isolated from Aspergillus niger by using an all-glass homogenizer followed by differential centrifugation. 2. The mitochondria oxidized the common intermediates of the tricarboxylic acid cycle, NADH(2) and the ascorbate-tetramethyl-p-phenylenediamine system. 3. High P/O ratios and control of respiration by ADP were obtained with all substrates tested. The av...

The development of highly efficient catalysts using inexpensive and earth-abundant metals is a crucial factor in large-scale commercialization direct methanol fuel cells (DMFCs). In this study, we explored new catalyst based on copper nanodendrites (CuNDs) supported carbon nanofibers/poly (para-phenylenediamine) (CNF/PpPD) nanocomposite for oxidation reaction (MOR). support was prepared paste e...

BACKGROUND The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood. OBJECTIVES Investigation of the elicitation response to the new, less-sensitizing PPD alternative 2-methoxymethyl-p-phenylenediamine (ME-PPD) under simulated hair dye use conditions. METHODS The cross-elicitation response to ME-PPD (2% in a hair ...

A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally fri...