Abstract Background and Aims Mitophagy activation is crucial for hypoxia signaling in acute kidney injury (AKI). Selective removal of damaged mitochondria mediated through a concerted function coding non-coding RNA expressions. Insights on HIF-1α lncRNA-regulated mitophagy mechanism are not known. The study aims to investigate the role hypoxia-inducible factor 1α (HIF-1α) regulated long (lncRNA...

P ATIENTS WITH LYMPHOMA, leukemia, multiple myeloma, or other conditions characterized by an altered immunologic state have an increased susceptibility to the manifestations of common viral infections. In such patients, disseminated infections with the DNA viruses, herpes simplex, and herpes zoster have carried a poor prognosis.1’2 Various attempts have been made to treat these disseminated inf...

the prevalence of type 2 diabetes mellitus (t2dm) is rising dramatically in the middle east, especially in the islamic republic of iran, but the genetic basis of type 2 diabetes in iran is poorly understood. polymorphisms of hepatocyte nuclear factor-1α (hnf-1α) and glucagon-like peptide-1 receptor (glp-1r) genes showed association with type 2 diabetes in several ethnic groups. in this study, w...

Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), citrate synthase (CS) activity C2C12 myoblasts. was titrated to three concentrations (PQQ) (10 nM, 100 1000 nM) treated for ...

Conjugates of methotrexate (MTX) and the nucleoside analogs 3-azidodeoxythymidine (AZT), iododeoxyuridine (IUdR) and dideoxycytidine (ddC) linked using poly(ethyleneglycol) are presented. In vitro cytotoxicity assays of the conjugates against drug resistant ovarian cell line A2780/AD are preformed and comparisons made to such assays performed for unconjugated (cocktail) systems. All systems tes...

BACKGROUND Hypoxia-inducible factor 1α (HIF-1α) is an important regulator of immune and inflammatory responses. We hypothesized that nasal allergic inflammation is attenuated by HIF-1α inhibition and strengthened by HIF-1α stabilization. OBJECTIVE To elucidate the role of HIF-1α in a murine model of allergic rhinitis (AR). METHODS Mice were pretreated with the HIF-1α inhibitor 2-methoxyestr...

The present study aimed to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) and MDR1/P-glycoprotein (P-gp) in human laryngeal squamous cell carcinoma (LSCC) tissues, and also to investigate the regulation of MDR1 gene expression by HIF-1α in Hep-2 cells under hypoxic conditions. The expression of HIF-1α and MDR1/P-gp in human LSCC tissues was examined using immunohistochemistry. ...

ii Acknowledgments I dedicate this work to my uncle Scott whose thirst for knowledge and positive attitude despite all odds was inspirational and I dedicate this to my beautiful wife Christina who somehow put up with me through all of this while she obtained her own degree from the LSU School of law. How she kept from doing me great physical harm I'll never know. I offer my heartfelt thanks to ...

Currently, it is not entirely clear whether hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of COX-2 expression and epithelial-to-mesenchymal transition (EMT), and whether these events affect the prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE). In this report the relationship between HIF-1α and COX-2 protein ex...