نتایج جستجو برای: 0290 and 0301
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PURPOSE The frequently expressed differentiation antigen tyrosinase-related protein-2 (TRP-2) has repeatedly been described as a target of spontaneous cytotoxic T-cell responses in melanoma patients, suggesting that it might be an ideal candidate antigen for T cell-based immunotherapy. As a prerequisite for immunization, T-cell epitopes have to be identified. Whereas a number of HLA class I-pre...
The HLA class II (DRB1 and DQB1) associations with sarcoidosis have been studied by several groups but often without consistent results. In this paper, we consider the hypothesis that observed inconsistencies relate to distinct, genetically encoded disease phenotypes which differ in prevalence between centres. We therefore typed HLA-DRB1 and DQB1 in 340 UK, 139 Dutch and 163 Japanese sarcoidosi...
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease seen primarily in elderly persons. It is characterized clinically by the development of tense bullae and by the presence of an antibasement membrane antibody. In BP, the antigens involved in the autoimmunity are epidermal basement membrane peptides BPAg1 and BPAg2. We have compared high resolution typing of major histocomp...
To the Editor—We would like to thank E. J. Minton and colleagues [1] for their recent paper confirming that DRB1∗11 and DQB1∗0301 alleles were associated with clearance of circulating hepatitis C virus (HCV) [1]. They confirmed the results of a study that we published 1 year ago [2]. We showed that the frequency of DQB1∗0301 and DRB1∗1101 alleles was higher among a group of French patients with...
Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with identical "broad" DR. He was apparently not sensitized to HLA antigens by complement-dependent cytotoxicity (CDC), with one previous transplantation 15 years previously. In post-transplantation monito...
Background: Based on the reports, high frequency of special alleles of HLA class II genes might be associated with susceptibility to or protective from a particular cancer. These alleles might vary depending on the geographical region. Here we investigate the association between alleles of HLA class II genes and breast cancer in Iranian women.Methods: 100 patients with pathologically proved bre...
Background: HLA genes are highly polymorphic and certain alleles are frequent only in specific populations. Therefore, HLA is a unique tool for studying the genetic relationship between different populations. Iranians are ethnically diverse people and one of the major ethnic groups in Iran is Lur population inhabiting along the central and southern parts of Zagros Chain Mountain. Objectives: Ge...
Use of precision farming technologies requires better understanding of soil variability in physical, hydraulic and chemical properties. Some of that variation is natural, some is the result of the management history of the field. So, to match agricultural inputs and practices to site-specific conditions, the factorial kriging algorithm (FKA) was used to analyze spatial variability in some soil ...
Nitrogen and carbon emissions and plant nutrient leaching during storage of solid deep litter from dairy cow houses was examined in this study. Included was an assessment of the potential for reducing emission and leaching losses by compaction, mixing and by covering the deep litter. During a composting period of 132 days from October 1998 to March 1999, emissions of NH3, N2O and CH4 and leachi...
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