The purine metabolic enzymes adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) are important in lymphocyte differentiation, and genetic deficiencies of either enzyme have been associated with hereditary immunodeficiency states. Both ADA and PNP activity were measured in null cell-enriched and T cell-enriched peripheral blood lymphocytes from 16 patients with the acquired immun...

Immunotherapy has drastically improved the survival prospect for advanced melanoma. Unfortunately, these treatments often come with cutaneous side effects which may cause patient to discontinue or delay therapy. To understand mechanism of immunotoxicity in relation clinical presentation, we characterized symptom clusters by and histologic morphology, severity rating, transcriptional analyses pa...

Circadian changes in the susceptibility of adult individuals of three cricket species: field cricket (Gryllus campestris), house cricket (Acheta domesticus), and tropical house cricket (Gryllodes sigillatus) to insecticides belonging to the group of synthetic pyrethroids (Bulldock 025 EC) and oxadiazine (Steward 30 WG) were tested in 2007 and 2008. The assessment included the intoxication of su...

Bats are known reservoirs of viral zoonoses. We report genetic characterization of a bat rotavirus (Bat/KE4852/07) detected in the feces of a straw-colored fruit bat (Eidolon helvum). Six bat rotavirus genes (viral protein [VP] 2, VP6, VP7, nonstructural protein [NSP] 2, NSP3, and NSP5) shared ancestry with other mammalian rotaviruses but were distantly related. The VP4 gene was nearly identica...

BACKGROUND Increased cytoplasmic HuR expression has been noted in several cancer types, where it may contribute to the increased cyclooxygenase-2 (COX-2) expression observed during tumorigenesis and metastasis. METHODS To assess the correlation between COX-2 and HuR in oral squamous cell carcinoma (OSCC), the expression patterns of HuR and COX-2 were assessed via immunohistochemistry analyses...

Search for inhibitors to insect proteases is one of many strategies control pests. Previous work has demonstrated successful purification effective from plant origin. Thus, the current study attempted purify protease locally available medicinal plants. The that ethanolic extracts Mimosa diplotricha leaves caused a significant 80% reduction in bovine trypsin activity. inhibitory property protein...

We report Very Large Telescope observations of 11 lensed quasars, designed to measure the redshifts of their lens galaxies. We successfully determined the redshifts for seven systems, five of which were previously unknown. The securely measured redshifts for the lensing galaxies are: HE0047−1756 z = 0.408; PMNJ0134−0931 z = 0.766; HE0230−2130 z = 0.522; HE0435−1223 z = 0.455; SDSS0924+021 z = 0...