Abstract Harnessing the cytotoxic capacity of CD8 T cells is central to efficacy immunotherapy and has revolutionized fight against cancer. However, despite encouraging success for select indications, immunotherapies still fail achieve durable effective outcomes certain cancer types in many patients. Failure often results from differentiating into an epigenetically controlled reinforced state k...

in this study, polyaniline molecule (emeraldine base) is modeled as a molecular wire and the effects of the metal/molecule coupling strength and the molecule length on the current-voltage (i-v) characteristics are numerically investigated. using a tight-binding hamiltonian model, the methods based on non-equilibrium green’s function theory, landauer formalism and newns-anderson model, our calcu...

Inspired by the $T^+_{cc}$ signal discovered LHCb Collaboration, we systematically investigate doubly heavy tetraquark states with molecule configuration $[Q_1\bar{q}_2][Q_3\bar{q}_4]$ ($Q=c$ and $b$, $q=u$, $d$ $s$) in a nonrelativistic quark model. The model involves color screening confinement potential, meson-exchange interactions one-gluon-exchange interactions. state $IJ^P=01^+$ is very l...

Acknowledgments I am grateful for the supervision of Dr. Vijaya Ramachandran during my undergraduate research. I have learned from her the fundamentals of theoretical Computer Science and the joy of doing research. Her tireless passion and motivation enlightens my way through many difficult problems. It is my honor to work with Dr. Ganeshkumar Ganapathy and Rezaul Chowdhury, with generous help ...

ii ACKNOWLEDGMENTS I dedicate my work to my parents Mr. Nageswara Rao and Mrs. Vijaya Lakshmi, my brother and sister-in law Mr. Sapta Nag and Mrs. Parimala and my grandparents Mr. Gandhi and Mrs. Sambrajam for their constant support and encouragement throughout my life. I am very grateful to my advisor Dr. A. Srivastava for his guidance, patience and understanding throughout this work. His sugg...

In the last talk of this conference, Joanne Walters-Wayland will discuss a continuum of minimizable properties of sublocales of a (completely regular) locale. By that is meant a property P such that above any dense sublocale S of a locale L there is a least sublocale having property P. Such properties induce a contraction of the lattice of prenuclei of the frame, i.e., an order-preserving map w...

Acknowledgements This Habilitation thesis presents my work of the last 5 years, mostly done at ETH Zurich and partly at University College London. This was a really exciting time, and I owe a great deal of gratitude to my numerous colleagues and friends. Price: For his friendship and inspiring discussions, both scientific and personal. David's style (best described as " light-hearted wisdom ") ...

Introduction Two large paediatric studies are currently underway in the U.S. to investigate efficacy and safety of MP29-02 (Dymista) in children, with a view to extending its indication to those aged ≥6 yrs. In line with FDA recommendations, these studies compare MP29-02 to placebo. To mimic the clinical trial design of these on-going pediatric studies, this meta-analysis assessed all data avai...