Retinoids exhibit chemotherapeutic and chemopreventive activities, possibly due to their ability to modulate cell growth, differentiation, and apoptosis. These effects are thought to be mediated by nuclear retinoic acid (RA) receptors (RARs) and retinoid X receptors, each of which includes three subtypes (alpha, beta, and gamma) that act as transcription factors. To determine whether RARs play ...

BACKGROUND/AIMS Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. In this study, we examined the significance of OPN in endometrial cancer. ...

Repair of human endometrium after menstruation and preparation of the endometrium for implantation involves profound angiogenic changes. Vascular endothelial cell growth factor (VEGF) is a recently identified growth factor with significant angiogenic properties. Four species of mRNA encoding VEGFs were identified in human endometrium and myometrium. All species were present throughout the menst...

Human-elephant conflict (HEC) is a serious threat to elephants and can cause major economic losses. It is widely accepted that reduction of HEC will often require community-based methods for repelling elephants but there are few tests of such methods. We tested community-based crop-guarding methods with and without novel chili-based elephant deterrents and describe changes in farmers' willingne...

Human-elephant conflict (HEC) threatens the survival of endangered Asian elephants (Elephas maximus). Translocating "problem-elephants" is an important HEC mitigation and elephant conservation strategy across elephant range, with hundreds translocated annually. In the first comprehensive assessment of elephant translocation, we monitored 16 translocations in Sri Lanka with GPS collars. All tran...

As cyclin-dependent kinases (CDKs) regulate cell cycle progression and RNA transcription, CDKs are attractive targets for creating cancer cell treatments. In this study we investigated the effects of the small molecular agent NU6140 (inhibits CDK2 and cyclin A interaction) on human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells via the expression of transcription factors...

and Applied Analysis 3 Table 1: Solitary wave Amp. 0.3 and the errors in L2 and L∞ norms for u, Q 1 , Q 2 , and Q 3 at t = 20, h = 0.125, Δt = 0.1, and −40 ≤ x ≤ 60. Method Time Q 1 Q 2 Q 3 L 2 for u L∞ for u Our method 0 3.9797 0.8104 2.5787 0 0 4 3.9797 0.8104 2.5786 3.6304e − 004 5.2892e − 005 8 3.9797 0.8104 2.5786 7.2873e − 004 5.8664e − 005 12 3.9797 0.8104 2.5787 1.0817e − 003 6.3283e − ...

This paper develops a framework for regional scale flood modeling that integrates NEXRAD Level III rainfall, GIS, and a hydrological model (HEC-HMS/RAS). The San Antonio River Basin (about 4000 square miles, 10,000 km2) in Central Texas, USA, is the domain of the study because it is a region subject to frequent occurrences of severe flash flooding. A major flood in the summer of 2002 is chosen ...

Analytical approximations to Einstein integrals are proposed. The approximations represented by two fast-converging series are valid for all values of their arguments. Accordingly, the algorithm can be easily incorporated into professional software like HEC-RAS or HEC-6 with minimum computational effort. DOI: 10.1061/(ASCE)0733-9429(2004)130:12(1198) CE Database subject headings: Bed load; Susp...