نتایج جستجو برای: گیرنده her2

تعداد نتایج: 20398  

2016
F. Du P. Yuan Z. T. Zhao Z. Yang T. Wang J. D. Zhao Y. Luo F. Ma J. Y. Wang Y. Fan R. G. Cai P. Zhang Q. Li Y. M. Song B. H. Xu

“The following institutions participated in this study: Fudan University Shanghai Cancer Center; Zhejiang Cancer Hospital; Guangdong General Hospital; Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology; Nanfang Hospital, Southern Medical University; Sun Yat-Sen University Cancer Hospital; West China Hospital, Sichuan University; Harbin Medical University Cance...

Journal: :avicenna journal of medical biochemistry 0
mohammad nadri department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, ir iran mohammad soukhtanloo department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, ir iran; cancer molecular pathology research center, ghaem hospital, school of medicine, mashhad university of medical sciences, mashhad, ir iran amir hosein jafarian cancer molecular pathology research center, ghaem hospital, school of medicine, mashhad university of medical sciences, mashhad, ir iran mahboobeh alamdari department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, ir iran mohsen sisakhti department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, ir iran tayebeh kianoush department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, ir iran

results isotype of 1f1 clone was determined to be igg1, which reacted with native protein in the western blot experiment and stained 20% of the membrane of neoplastic cells overexpressing her2 with 3+ grade. however, 3l5 clone showed a low reaction (10%) with native her2 in immunohistochemistry. conclusions the results of both western blotting and immunohistochemistry showed that native her2 ca...

Ali Borhani, Majid Shakiba, Masumeh Gity, Mehrdad Mokri, Morteza Atri, Nasim Batavani,

Background: Estrogen-negative breast cancers have different clinical course, prognostic features and treatment response in comparison to estrogen receptor-positive (ER-positive) breast cancers. Human epidermal growth factor receptor 2 (HER2) oncoprotein has found to have a pivotal role in natural cell growth and cell division and is suggested to be directly related to tumor invasiveness in brea...

Background and Objective:Determination of HER2 gene is crucial in breast carcinoma management and prognosis, as HER2 alterations are linked to a shorter disease-free period, overall survival and resistance to tamoxifen anti-estrogen therapy and other chemotherapy regimens, regardless of the nodal or hormone receptor status. This study aimed to...

Background: Colorectal cancer is the fourth most common cancer in the world. It is the third largest risk factor for cancer individuals. The number of new cases is rising since 1975. Hyper activities of EGFR family have been reported in various cancers. The purpose of this study was to investigate the expression levels of HER2 in colorectal cancer and its possible association with advanced stag...

Journal: :iranian journal of pathology 0
zaidoon a. musa al-emamain al-kadhimain medical city, baghdad, iraq ban j. qasim dept. of pathology and forensic medicine, college of medicine, al-nahrain university, baghdad, iraq a.wahab a.k. al shaikhly dept. of pharmacy (dean)/ al rasheed university college, baghdad, iraq

background and objective:determination of her2 gene is crucial in breast carcinoma management and prognosis, as her2 alterations are linked to a shorter disease-free period, overall survival and resistance to tamoxifen anti-estrogen therapy and other chemotherapy regimens, regardless of the nodal or hormone receptor status. this study aimed to estimate her2 gene status of infiltrative mammary c...

بذرافشانی, محمد رضا , حسینی, فاطمه السادات , راستین نیا, سمیه , پورسیدی, بهرام ,

زمینه و هدف: وجود تکثیر ژن HER2 جهت پیش بینی وضعیت و انتخاب درمان، در بیماران مبتلا به سرطان پستان، تعیین کننده است. آنالیز تکثیر ژن Her-2 با استفاده از روش MLPA  که روش جدید در  بررسی های بالینی می باشد ، انجام گردید. مواد و روش کار: در این مطالعه توصیفی، تعداد 60 بیمار مبتلا به سرطان سینه را که در بیمارستان افضلی پور کرمان، جراحی شدند، از نظر مضاعف شدگی HER2 به روش MLPA مورد مطالعه قرار گرفتن...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده علوم 1389

رسپتور فاکتور رشد اپیدرمی her2 به طور مکرر در سرطان سینه و چندین تومور جامد دیگر افزایش بیان یافته که این افزایش بیان، عمدتاً ناشی از تزاید ژن آن است. تزاید ژن her2 و یا افزایش بیان پروتئین آن در 10 تا 34% از بیماران سرطان سینه مشاهده شده و بر روی پیشرفت، درمان و تشخیص بیماری موثر است. در نتیجه بررسی صحیح وضعیت her2 تومور، در اداره بیماری و انتخاب صحیح بیمارانی که قادر به درمان با داروی جدید ترا...

Journal: :middle east journal of cancer 0
zahra mojtahedi shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran sharareh solati dalaki department of obstetrics and gynecology, shiraz university of medical sciences, shiraz, iran alamtaj samsami dehaghani department of obstetrics and gynecology, shiraz university of medical sciences, shiraz, iran minoo robati department of obstetrics and gynecology, shiraz university of medical sciences, shiraz, iran ahmad monabati department of pathology, shiraz university of medical sciences, shiraz, iran mohammad javad fattahi shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran

introduction : the proto-oncogene her2 plays a key role in the control of cellular proliferation. its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer. materials and methods : in the present study, serum her2 levels were investigated in patients diagnosed with epithelial ovarian cancer. serum her2 levels were detected by an elisa c...

مقدمه: مطالعات اپیدمیولوژیک انجام شده در ایران نشان‌دهنده روند افزایشی ابتلاء به سرطان پستان است و در حال حاضر به یکی از نگرانی‌های اصلی پژوهشگران تبدیل شده است. در مناطق و جمعیت‌های گوناگون، بررسی‌های متعددی انجام شده که هر کدام عوامل مختلفی را بر میزان بقاء بیماران مؤثر دانسته‌اند. مطالعه حاضر با هدف بررسی عوامل مؤثر بر پیش‌آگهی بیماران مبتلا به سرطان پستان، در بازه زمانی 5 ساله انجام شد. رو...

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