The constitutive androstane receptor (CAR) NR1I3 is a transcription factor that upon activation by xenobiotics induces transcription of drug-metabolizing and drug transporter genes. Our goal was to identify whether alternative splicing of CAR makes an important contribution to the generation of novel CAR proteins. The wild-type CAR mRNA (CAR.1) and splice variants (SVs) were amplified from huma...

Coxsackie and adenovirus receptor (CAR) was first known as a virus receptor. Recently, it is also known to have tumor suppressive activity such as inhibition of cell proliferation, migration, and invasion. It is important to understand how CAR expression can be regulated in cancers. Based on an existence of putative Sp1 binding site within CAR promoter, we investigated whether indeed Sp1 is inv...

today, the number of drivers and traffic users is increasing. so, it is necessary to know that the human factor has the most important factor in the traffic. thus, any behavior change or fault that arises from human factor (for example drivers) can have inappropriate impacts on the traffic. so, it is important that traffic users be trained about the effectiveness and attention to the traffic si...

over the past few years, the subculture of exhibitionist car driving has attracted the attention of any social and cultural researchers in our country. these phenomena have been formed in interaction with general social trends. therefore, the study of these phenomena would facilitate a better understanding of these trends and currents. the present paper is an attempt to study the grounds that c...

traumatic brain injury (tbi) is one of the serious neurodisorders commonly caused by car accidents and sports. preventive measures are highly recommended to reduce the risk and number of tbi cases. after tbi, the primary injury to the brain initiates a secondary injury process that spreads via multiple molecular mechanisms in the pathogenesis of tbi. many studies in animals using cdna microarra...

purpose : to report a case of purtscher retinopathy associated with valsalva retinopathy after car accident methods : a 54-year-old man presented with a sudden visual loss in his left eye after car accident. fundus examination of the left eye showed cotton-wool spots and retinal hemorrhages in the posterior pole associated with subhyaloid hemorrhage in macula. results : fundus examination showe...

abstract background and purpose: according to the reported problems in area of the inappropriateness of water quality which used for washing and staining of car apparatuses in a car factory, this research was carried out for identification of physical, chemical, and microbiological characteristics of the consumed water in babol car factory, iran. materials and methods: physical and chemical par...

background and aim: injuries from traffic accidents are a major public health problem, and the third leading cause of mortality in people aged 1 to 40 years. each year 31.8 persons per hundred thousands of iranians are killed in car accidents. neighboring of north khorasan province with razavi khorasan, a province with a lot of pilgrims caused a large number of passengers travel via north khora...

The liver X receptor (LXR) and constitutive androstane receptor (CAR) are two nuclear receptors postulated to have distinct functions. LXR is a sterol sensor that promotes lipogenesis, whereas CAR is a xenosensor that controls xenobiotic responses. Here, we show that LXRα and CAR are functionally related in vivo. Loss of CAR increased the expression of lipogenic LXR target genes, leading to inc...