Miller and Baumann (4), in a study of the rela tionship of the chemical structure of p-dimethyl aminoazobenzene (DAB) to its potency in induc ing hepatoma formation in rats, prepared a series of methylated derivatives of the parent compound. These workers found that 3'-methy!-DAB was not only more active than the parent compound but was the most active of all the azo dyes investigated up to tha...

The mechanical and thermal properties of poly{2,6-diimidazo[4,5-b:4′5′-e] pyridinylene1,4(2,5-dihydroxy) phenylene} (PIPD)-3,3-diaminobenzidine (DAB) fibers were analyzed. Compared to other types of benzimidazole fiber structures and properties, PIPD-DAB is distinguished by a unique combination of strength, tensile modulus, and thermal properties. The PIPD polymer was prepared from 2,3,5,6-tetr...

A high yield synthesis of a new, extremely bulky anionic gallium(I) N-heterocyclic carbene analogue, [(DAB*)Ga:](-) (DAB* = {N(Ar*)C(H)}(2), Ar* = C(6)H(2){C(H)Ph(2)}(2)Me-2,6,4) has been developed and four monomeric sodium complexes of the heterocycle have been crystallographically characterised. The gallium(I) heterocycle has been utilised in the preparations of the heteroleptic zinc and cadm...

The electronic structures of two uranium compounds supported by redox-active α-diimine ligands, ((Mes)DAB(Me))(2)U(THF) (1) and Cp(2)U((Mes)DAB(Me)) (2) ((Mes)DAB(Me) = [ArN═C(Me)C(Me)═NAr]; Ar = 2,4,6-trimethylphenyl (Mes)), have been investigated using both density functional theory and multiconfigurational self-consistent field methods. Results from these studies have established that both u...

Radio broadcasting technology in this era of compact disc is expected to deliver high quality audio programmes in mobile environment. The Eureka-147 Digital Audio Broadcasting (DAB) system with coded OFDM technology accomplish this demand by making receivers highly robust against effects of multipath fading environment. In this paper, we have analyzed the performance of DAB system conforming to...

The new digital radio system DAB (Digital Audio Broadcasting), developed within the Eureka 147 project is a very innovative and universal multimedia broadcast system that has the potential to replace existing AM and FM audio broadcast services in many parts of the world in the near future. DAB employs coded OFDM technology that enables it for mobile reception and makes receivers highly robust a...

A chemo-enzymatic strategy for the preparation of 2-aminomethyl derivatives of (2R,3R,4R)-2-(hydroxymethyl)pyrrolidine-3,4-diol (also called 1,4-dideoxy-1,4-imino-D-arabinitol, DAB) and its enantiomer LAB is presented. The synthesis is based on the enzymatic preparation of DAB and LAB followed by the chemical modification of their hydroxymethyl functionality to afford diverse 2-aminomethyl deri...

BACKGROUND Tumor necrosis factor-α (TNF) is strongly implicated in the development of acute respiratory distress syndrome (ARDS), but its potential as a therapeutic target has been hampered by its complex biology. TNF signals through two receptors, p55 and p75, which play differential roles in pulmonary edema formation during ARDS. We have recently shown that inhibition of p55 by a novel domain...

A nucleosomal protein, high mobility group box 1 (HMGB1) is known to be a late mediator of sepsis. Dabrafenib is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Inhibition of HMGB1 and renewal of vascular integrity is appearing as an engaging therapeutic strategy in the administration of severe sepsis or septic shock. Here, we examined the effects of dabra...