The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases. The objectives of this study were t...

In view of the claim that low 25-hydroxyvitamin D (25-OHD) concentrations may contribute to the pathogenesis of bone disease in patients with beta thalassaemia major and iron overload, we have assessed the concentrations of 25-OHD, 1 alpha,25 dihydroxyvitamin D (1 alpha,25(OH)2D), parathyroid hormone, and osteocalcin in such patients. 25-OHD concentrations were significantly lower in patients w...

background: both vitamin d deficiency and hypertension are prevalent in the general population. several observations indicate an association between vitamin d deficiency and high blood pressure. the present case-control study aimed to compare serum 25-hydroxyvitamin d (25-ohd) in hypertensive patients versus healthy controls. methods: one hundred patients aged 30-60 years with hypertension (htn...

The effects of blood levels of 25-hydroxyvitamin D (25-OHD) on the risk of total, low-, and high-grade prostate cancer were examined in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Prostate Cancer Prevention Trial (PCPT). In the SELECT study, plasma 25-OHD levels were associated with a linear decrease in prostate cancer risk for high-grade cancers in African American men ...

Background: Benign paroxysmal positional vertigo (BPPV) is a condition with recurrent attacks in a significant proportion of patients. The present case- control study was conducted to assess the influence of serum vitamin D normalization on recurrent attacks of vitamin D deficient patients. Methods: Diagnosis of BPPV was made based on history and clinical examination and exclusion of other c...

background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited in­formation on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the dis­ease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and car­ried out to determine the variation of...

The study is devoted to the creation of a dataset protein structural motifs 3β-corner type. relevance and importance creating 3β-corners determined by fact that this structure can be an embryo or ready-made block in process folding, also act as independent object research field biology. contains 3β-corner-like structures are geometrically similar 3β-corners. consists 45,896 structures. For each...

background: vitamin d deficiency seems to be associated with pulmonary function deterioration. the present study was designed to investigate the relationship between serum vitamin d and forced expiratory volume in patients with chronic obstructive pulmonary disease (copd). methods: from september 2011 to april 2012 eighty consecutive patients with copd presented to an outpatient clinic of babol...

In 110 white West Midlands children serum 25-hydroxy vitamin D (25-OHD) concentrations showed a pronounced seasonal variation, the values being highest in August and lowest in February. The concentrations correlated significantly both with recorded sunlight and with seasonal ultraviolet energy of the sunlight. Children who had had a seaside holiday the previous summer had a higher mean 25-OHD c...