The interaction between tumor cells and their microenvironment is an essential aspect of tumor development. Therefore, understanding how this microenvironment communicates with tumor cells is crucial for the development of new anti-cancer therapies. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression. They are secreted into the extracellular medium in vesicles called exoso...

رۆژنامهڤانی‌ ئێك ژ ژێده‌رێن گرنگه‌ بۆ په‌یداكرنا پێزانینێن مێژوویێ ل دور هه‌ر بابه‌ته‌كێ گرێدای مێژوویێ، ب تایبەت ئەو رۆژنامە ئەوێن سەردەمی رویدانا دەرچووین، چۆنکە گەلەک دەم سەردا نەچوویە، له‌ورا زۆر ڤه‌كۆلینێن ئه‌كادیمى د ناڤ رۆپه‌لێن ئه‌وانا دا هویرى بهێنه‌ ئه‌نجامدان، چونكه‌ گه‌له‌ك جاران ئه‌و پێزانین دناڤ ئه‌وان رۆژناما بنه‌ جهێ باوه‌ریێ، لێ هه‌مان ده‌م هنده‌ك ئه‌واندا هه‌نه‌ شاشن و دورن را...

The thyroid hormone receptors (TRs) mediate tumor suppressive effects in hepatocarcinoma and breast cancer cells. Here we show that incubation of hepatocarcinoma SK-hep1 cells expressing TRb with the thyroid hormone T3 induces transcription of the polycistronic message coding for microRNAs 424 and 503. TRb binds to the promoter region of these miRNAs and T3 induces an exchange of corepressors a...

Objective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on miR-503 and CDC25 expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (2...

The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted activation of three ER stress sensors, namely IRE1, PERK and ATF6. Global approaches in several cellular contexts have revealed that UPR regulates the expression of many miRNAs tha...

sludge production is an avoidable problem arising from the treatment of wastewater. the sludge remained after municipal wastewater treatment contains considerable amounts of various contaminants and if is not properly handled and disposed, it may produce extensive health hazards. on the other hand, this sludge has benefits for plants and soils. thereupon, land application of sludge has received...