نتایج جستجو برای: ژن timp

تعداد نتایج: 19617  

1999
Kurtis E. Bachman James G. Herman Paul G. Corn Adrian Merlo Joseph F. Costello Webster K. Cavenee Stephen B. Baylin Jeremy R. Graff

Tissue inhibitor of metalloproteinase-3 (TIMP-3) antagonizes matrix metalloproteinase activity and can suppress tumor growth, angiogenesis, invasion, and metastasis. Loss of TIMP-3 has been related to the acquisition of tumorigenesis. Herein, we show that TIMP-3 is silenced in association with aberrant promoter-region methylation in cell lines derived from human cancers. TIMP-3 expression was r...

Journal: :International journal of cancer 2010
Nor Eddine Sounni Dmitri V Rozanov Albert G Remacle Vladislav S Golubkov Agnes Noel Alex Y Strongin

Both invasion-promoting MT1-MMP and its physiological inhibitor TIMP-2 play a significant role in tumorigenesis and are identified in the most aggressive cancers. Despite its antiproteolytic effects in vitro, clinical data suggest that TIMP-2 expression is positively associated with tumor recurrence, thus emphasizing the wide-ranging role of TIMP-2 in malignancies. To shed light on this role of...

2010
Yi Shen Ingrid G. Winkler Valerie Barbier Natalie A. Sims Jean Hendy Jean-Pierre Lévesque

BACKGROUND Tissue inhibitor of metalloproteinases-3 (TIMP-3) inhibits matrix metalloproteinases and membrane-bound sheddases. TIMP-3 is associated with the extracellular matrix and is expressed in highly remodeling tissues. TIMP-3 function in the hematopoietic system is unknown. METHODOLOGY/PRINCIPAL FINDINGS We now report that TIMP-3 is highly expressed in the endosteal region of the bone ma...

Journal: :Neuroscience 2007
Y Koyama A Baba T Matsuda

Production of tissue inhibitors of matrix metalloproteinases (TIMPs), a family of secreted proteins with inhibitory actions on matrix metalloproteinases (MMPs), is up-regulated following nerve injuries and is suggested to have protective effects against MMP-mediated tissue damages. To clarify the extracellular signals involved in TIMP production in the brain, the effects of endothelins (ETs), a...

2014
Rosemarie Chirco D'Angelo Xu-Wen Liu Abdo J. Najy Young Suk Jung Joshua Won Karl X. Chai Rafael Fridman Hyeong-Reh Choi Kim

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates intracellular signaling networks for inhibition of apoptosis. Tetraspanin (CD63), a cell surface binding partner for TIMP-1, was previously shown to regulate integrin-mediated survival pathways in the human breast epithelial cell line MCF10A. In the current study, we show that TIMP-1 expression induces phenotypic changes in cell morphol...

Journal: :Molecular cancer research : MCR 2014
Rosemarie Chirco D'Angelo Xu-Wen Liu Abdo J Najy Young Suk Jung Joshua Won Karl X Chai Rafael Fridman Hyeong-Reh Choi Kim

UNLABELLED Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates intracellular signaling networks for inhibition of apoptosis. Tetraspanin (CD63), a cell surface binding partner for TIMP-1, was previously shown to regulate integrin-mediated survival pathways in the human breast epithelial cell line MCF10A. In the current study, we show that TIMP-1 expression induces phenotypic changes in c...

Journal: :European journal of cancer 2010
Helgi Birgisson Hans J Nielsen Ib Jarle Christensen Bengt Glimelius Nils Brünner

BACKGROUND Previous studies have suggested plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) as a stage independent prognostic marker in colorectal cancer (CRC) patients. The aim was to validate plasma TIMP-1 and serum carcino-embryonic antigen (CEA) levels as prognostic indicators in an independent population-based cohort of patients with CRC. PATIENTS AND METHODS During 2000-2003, pl...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 1999
A Kranzhöfer A H Baker S J George A C Newby

Degradation of the extracellular basement membrane is implicated in atherosclerosis, restenosis after angioplasty, and intimal thickening of vein grafts. Upregulation of metalloproteinase (MMP)-2 and MMP-9 accompanies neointima formation in cholesterol-fed rabbits, in rat and pig models of angioplasty, and in organ cultures of human saphenous veins. MMPs are inhibited by binding to tissue inhib...

Journal: :Cancer research 2001
H F Bigg C J Morrison G S Butler M A Bogoyevitch Z Wang P D Soloway C M Overall

The tissue inhibitors of metalloproteinases 1-4 (TIMPs) have discrete regulatory roles in the activation of matrix metalloproteinase (MMP)-2 (gelatinase A), an important basement membrane-degrading MMP pivotal to tumor metastasis and angiogenesis. TIMP-2 binds to both the hemopexin C domain of progelatinase A and the active site of membrane type-1 (MT1) MMP. This trimeric complex presents the c...

2012
Naohiko Inagaki Kimihiko Kato Toshiki Kawamiya Hideki Horibe Takeshi Hibino Kiyoshi Yokoi Yasuaki Dohi Toyoaki Murohara Genjiro Kimura

Background: Increases in levels of matrix metalloproteinase (MMP) and tissue inhibitor of matrix metalloproteinase (TIMP) occur in acute aortic dissection (AAD); however, their association with prognosis in AAD remains largely unknown. We studied the use of MMP and TIMP in predicting long-term outcomes in medically controlled AAD patients. Methods: A total of 82 patients were enrolled (15 Stanf...

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