نتایج جستجو برای: ژن stk15

تعداد نتایج: 15850  

2017
Takayuki Iwamoto Toyomasa Katagiri Naoki Niikura Yuichiro Miyoshi Mariko Kochi Tomohiro Nogami Tadahiko Shien Takayuki Motoki Naruto Taira Masako Omori Yutaka Tokuda Toshiyoshi Fujiwara Hiroyoshi Doihara Balazs Gyorffy Junji Matsuoka

BACKGROUND The purpose of this study was to test whether immunohistochemical (IHC) Ki67 levels after short-term preoperative hormone therapy (post-Ki67) predict similar numbers of patients with favorable prognoses as genomic markers. RESULTS Thirty paired cases (60 samples) were enrolled in this study. Post-Ki67 levels were significantly lower than pre-treatment Ki67 levels (P < 0.001). Post-...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Yung-Ming Jeng Shian-Yang Peng Chiao-Ying Lin Hey-Chi Hsu

PURPOSE Aurora-A/STK15/BTAK, a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation. The purpose of this study was to investigate the expression and amplification of Aurora-A in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN Aurora-A mRNA levels were measured in 224 HCCs and 199 paired nontumorous l...

Journal: :Journal of the National Cancer Institute 1999
H Katayama T Ota F Jisaki Y Ueda T Tanaka S Odashima F Suzuki Y Terada M Tatsuka

Loss of chromosomal integrity as well as genomic stability is considered to act as a driving force during the processes of tumorigenesis and tumor progression (1–3). Recently, two kinase genes involved in mitosis, the genes for aurora and IPL1l ike midbodyassociated protein kinase-1 (4,5) [AIM1, registered in UniGene and also known as aurora1 (6) and ARK2 (7)] and for serine/threonine kinase-6 ...

Journal: :Cancer research 2003
Maria W Smith Zhaoxia N Yue Gary K Geiss Natalya Y Sadovnikova Victoria S Carter Loreto Boix Catherine A Lazaro Gary B Rosenberg Roger E Bumgarner Nelson Fausto Jordi Bruix Michael G Katze

Hepatocellular carcinoma (HCC) is a common primary cancer associated frequently with hepatitis C virus (HCV). To gain insight into the molecular mechanisms of hepatocarcinogenesis, and to identify potential HCC markers, we performed cDNA microarray analysis on surgical liver samples from 20 HCV-infected patients. RNA from individual tumors was compared with RNA isolated from adjacent nontumor t...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Tong Tong Yali Zhong Jianping Kong Lijia Dong Yongmei Song Ming Fu Zhihua Liu Mingrong Wang Liping Guo Shixin Lu Ming Wu Qimin Zhan

PURPOSE Aurora-A/STK15/BTAK, a centrosome-associated oncogenic protein, is implicated in the control of mitosis. Overexpression of Aurora-A has been shown to result in chromosomal aberration and genomic instability. Multiple lines of evidence indicate that Aurora-A induces cell malignant transformation. In the current study, we are interested in investigating the expression of Aurora-A in human...

Journal: :Carcinogenesis 2004
Tong Sun Xiaoping Miao Jinwei Wang Wen Tan Yifeng Zhou Chunyuan Yu Dongxin Lin

Aurora-A/BTAK/STK15, involved in regulating centrosomes and chromosome segregation, is overexpressed in human breast carcinoma and other cancers. The Phe31-->Ile polymorphism in Aurora A alters the kinase function, with the Ile31 variant being preferentially amplified and associated with degree of aneuploidy in human tumors. We have previously shown that the Phe31Ile polymorphism is associated ...

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