نتایج جستجو برای: ژن homer 1a
تعداد نتایج: 48605 فیلتر نتایج به سال:
Abnormal metabotropic glutamate receptor 5 (mGluR5) function, as a result of disrupted scaffolding with its binding partner Homer, contributes to the pathophysiology of fragile X syndrome, a common inherited form of intellectual disability and autism caused by mutations in Fmr1. How loss of Fmr1 disrupts mGluR5-Homer scaffolds is unknown, and little is known about the dynamic regulation of mGlu...
Group I metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-r...
بیماری آنفلوانزا یکی از مهم ترین بیماری های ویروسی طیور صنعتی است. در این مطالعه، توالی ژن نورآمینیداز دو سویه ویروس آنفلوانزای طیور شامل 1998/101a/chicken/iran/zmt- و 2006/1a/chicken/iran/ngv- مورد بررسی قرار گرفت. ویروس اولی در سال 1377 از موارد اولیه همه گیری آنفلوانزا و ویروس دومی از همه گیری آنفلوانزای طیور در گله های گوشتی با تلفات بالا در سال 1385 جدا شده است. آمینواسید های محل جذب خونی ...
Drosophila enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain proteins regulate signal transduction at the neuronal and immunologic synapse. Despite shared cell biologic machinery at these synapses, the regulation of client proteins that transmit synaptic activity to the nucleus is likely to be different. Homer-3, a member of the EVH1 family, is expressed in the t...
به منظور مقایسه تفاوت ساختاری و تنظیم اسمزی ساک های پیلوریک در بچه ماهیان هم سن (دو تابستانه) آزاد خزر در اوزان مختلف (5، 10، 15، 20، 25 و 30 گرم)، در دو محیط آب شیرین و لب شور (ppt13)، تعداد 360 قطعه بچه ماهی پس از رقم بندی به تعداد مساوی 30 قطعه ای و نگهداری به مدت یک ماه مورد استفاده قرار گرفتند. در حالیکه تلفات معنی داری در آب شیرین دیده نشد، در آب لب شور میزان تلفات 25%، 20% و 8% به ترتیب ...
We present HOMER, an analysis and visualization tool for ontology alignment. HOMER features a radial-graph display GUI, a complete execution trace that allows the user to override and navigate to any match decisions during at runtime and a comparison mode that displays multiple alignments in parallel. HOMER contains a builtin plugin for the ILIADS ontology alignment algorithm, but other algorit...
Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that...
Homer protein was identified based on its rapid induction in rat hippocampal granule cell neurons following excitatory synaptic activity. Although the presence of the Homer gene in the peripheral tissues has been observed in previous reports, the physiological function of the Homer protein in these tissues has not been noted. In this experiment, a Homer-2a cDNA fragment was successfully amplifi...
The honest polynomial-time Turing (hp-T) reducibility, < :p, was first introduced by Homer (e.g. [6)). It has been known that the structural properties of the hp-T degrees of the recursive sets and those of the A; sets are closely related to the P =?NP problem. Homer [6,7] and Homer and Long [S] proved assuming P=NP that there is a As set which is <p minimal, and then Ambos-Spies [2] improved t...
Although oral administration of L-Dopa remains the best therapy for Parkinson disease, its long-term administration causes the appearance of abnormal involuntary movements such as dyskinesia. Although persistent striatal induction of some genes has already been associated with such pathologic profiles in hemiparkinsonian rats, molecular and cellular mechanisms underlying such long-term adaptati...
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