نتایج جستجو برای: ژن hand2

تعداد نتایج: 16041  

2014
Courtney Alexander Sarah Piloto Pierre Le Pabic Thomas F. Schilling

Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) cells, such as the subdivision of each pharyngeal arch into distinct dorsal (D) and ventral (V) elements. Wnt signaling has been implicated in many aspects of NC and craniofacial development, but its roles in D-V arch patterning remain unclear. To address this we blocked Wnt signaling in zebrafish...

Journal: :DMW - Deutsche Medizinische Wochenschrift 1887

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Takahiro Sato Yukiko Kurihara Rieko Asai Yumiko Kawamura Kazuo Tonami Yasunobu Uchijima Eglantine Heude Marc Ekker Giovanni Levi Hiroki Kurihara

Articulated jaws are highly conserved structures characteristic of gnathostome evolution. Epithelial-mesenchymal interactions within the first pharyngeal arch (PA1) instruct cephalic neural crest cells (CNCCs) to form the different skeletal elements of the jaws. The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation. He...

Journal: :Development 2005
David G McFadden Ana C Barbosa James A Richardson Michael D Schneider Deepak Srivastava Eric N Olson

The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at embryonic day 10.5 from right ventricular hypoplasia and vascular defects, whereas mice that lack Hand1 die at embryonic day 8.5 from placental and extra-embryonic abnormalities that preclude analysis of its potential ...

2017
Iveta Yotova Emily Hsu Catherine Do Aulona Gaba Matthias Sczabolcs Sabine Dekan Lukas Kenner Rene Wenzl Benjamin Tycko

Endometriosis is characterized by growth of endometrial-like tissue outside the uterine cavity. Since its pathogenesis may involve epigenetic changes, we used Illumina 450K Methylation Beadchips to profile CpG methylation in endometriosis stromal cells compared to stromal cells from normal endometrium. We validated and extended the Beadchip data using bisulfite sequencing (bis-seq), and analyze...

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