نتایج جستجو برای: ژن fhl1
تعداد نتایج: 15963 فیلتر نتایج به سال:
Systemic sclerosis (SSc) is characterized by excessive deposition of extracellular matrix (ECM) in the involved organs. Fibroblasts are activated and develop an uncontrolled synthesis collagen other ECM constituents. Previous studies have focused on cultured fibroblasts, but interpretation results been limited due to possible selection fibroblast populations. To better understand heterogeneity ...
In this issue of Cell, the Hall group describes how the rapamycin-sensitive TOR signaling network controls ribosomal protein (RP) gene expression via the Forkhead-like transcription factor FHL1 in budding yeast (Martin et al., 2004). These findings represent a crucial advance in our understanding of the mechanism by which TOR regulates ribosome biogenesis in response to environmental cues.
Correspondence To the Editor: The human four and a half LIM domain 1 (FHL1) gene, located on Xq26.3, encodes for a protein with only LIM domains. LIM domains, named after their initial discovery in the proteins Lin11, Isl‑1, and Mec‑3, are cysteine‑rich protein motifs composed of two contiguous zinc finger domains separated by a two‑amino acid residue hydrophobic linker. At least three splice p...
Systemic sclerosis (SSc) is a chronic autoimmune disease causing vasculopathy and fibrosis in the skin vital organs. Following an inflammatory reaction, fibroblasts connective tissues become activated myofibroblasts secrete excessive amounts of ECM related proteins, such as collagen, creating fibrosis. Many studies have been carried out culture, however, information obtained remains limited due...
The four-and-a-half LIM (FHL) proteins belong to a family of LIM-only proteins that regulate cell proliferation, differentiation, and apoptosis. The exact functions of each FHL protein in cancer development and progression remain unknown. Here we report that FHL1, FHL2, and FHL3 physically and functionally interact with Smad2, Smad3, and Smad4, important regulators of cancer development and pro...
Age-related macular degeneration is a leading form of blindness in Western countries and is associated with a common SNP (rs 1061170/Y402H) in the Factor H gene, which encodes the two complement inhibitors Factor H and FHL1. However, the functional consequences of this Tyr(402) His exchange in domain 7 are not precisely defined. In this study, we show that the Tyr(402) His sequence variation af...
Cell-size homeostasis entails a fundamental balance between growth and division. The budding yeast Saccharomyces cerevisiae establishes this balance by enforcing growth to a critical cell size prior to cell cycle commitment (Start) in late G1 phase. Nutrients modulate the critical size threshold, such that cells are large in rich medium and small in poor medium. Here, we show that two potent ne...
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