During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellu...

Objective: Determine the validity of the TRT_S2012 software in to assess the total reaction time (TRT) with a simple visual stimulus (TRTSimple) and mental fatigue from TRT (TRTFatigue). Methods: Three types of validation were applied: a) concurrent, for determining the correlation between the TRT_S2012 Software and Vienna Test System (VTS), b) content of a sample of adults, and c)mechanical, u...

BACKGROUND High lactate dehydrogenase (LDH) is associated with a large tumor burden in extensive-disease small-cell lung cancer (ED-SCLC). This study evaluated the benefit of additional thoracic radiotherapy (TRT) in patients with ED-SCLC with elevated LDH. METHODS We analyzed 94 patients with ED-SCLC and evaluated LDH at Sun Yat-sen University Cancer Center during the period between January ...

Cross-language Information Retrieval requires good methods for translating cross-lingual spelling variants which are not covered by the available dictionary resources. FITE-TRT is an established method employing frequency-based identification of translation equivalents received from transformation rule based translation. This study further develops and evaluates the FITE-TRT method. The paper c...

The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the advances in radionuclide production and labeling as well as by the improvement in the knowledge of appropriate and specific molecular targets. In recent years, different studies ...

L-Homoserine was tritylated via its silylated product with Me2SiCl2 or Ph2SiCl2 in 65-68% yield. Also N-Trt-L-methionine upon treatment with Mel and degradation of the resulting sulfonium salt with KOH yielded N-Trt-L-homoserine in 75% yield. Both routes provided N-Trityl-L-homoserine with identical physical data. In contrast to N-alkyloxycarbonyl-L-homoserine derivatives, N-Trt-L-homoserine sh...

BACKGROUND Patients with late-onset hypogonadism (LOH) benefit from testosterone replacement by improvement in the parameters of the metabolic syndrome, but fat cell morphology in these patients is still unclear. This study aims to determine the effect of testosterone replacement on the morphology of fat cells in subcutaneous and visceral adipose tissue and on erectile function in hypogonadal a...

The objective of this observational field study was to investigate the effect of an alternative intermittent lighting program (13L: 5D: 1L: 5D – Trt) vs. standard lighting program (16L: 8D – Ctrl) on production performance of laying-hen parent flocks. Two houses of 15,000 Hy-Line brown parent-stock hens each were used for the comparative study. Hen-day egg production (HDEP), eggs per hen ho...

Purpose The visual Text Reception Threshold (TRT) test (Zekveld et al., 2007) has been designed to assess modality-general factors relevant for speech perception in noise. In the last decade, the test has been adopted in audiology labs worldwide. The 1st aim of this study was to examine which factors best predict interindividual differences in the TRT. Second, we aimed to assess the relationshi...