ACY-241 is a novel, orally available and selective histone deacetylase (HDAC) 6 inhibitor in Phase 1b clinical development in multiple myeloma (NCT 02400242). Like the structurally related drug ACY-1215 (ricolinostat), ACY-241 has the potential for a substantially reduced side effect profile versus current nonselective HDAC inhibitor drug candidates due to reduced potency against Class I HDACs ...

published: Epilepsia 46(8);82[1.196]2005 Minnesota Epilepsy Group, P.A. 225 Smith Avenue N., Suite 201 St. Paul, MN 55102 Phone: (651) 241-5290 Fax: (651) 241-5248

An unusual psychrophilic green alga was isolated from the deepest portion of the photic zone (o0.1% of incident PAR) at a depth of 17m in the permanently ice-covered lake, Lake Bonney, Antarctica. Here we identify and report the first detailed morphological and molecular examination of this Antarctic green alga, which we refer to as strain UWO 241. To determine the taxonomic identity, UWO 241 w...

The integral bioluminescence (BL) intensity of live Photobacterium phosphoreum cells (strain 1883 IBSO), sampled at the stationary growth stage (20 h), was monitored for further 300 h in the absence (control) and presence of (241)Am (an α-emitting radionuclide of a high specific activity) in the growth medium. The activity concentration of (241)Am was 2 kBq l(-1); [(241)Am]=6.5×10(-11) M. Paral...

High-resolution neutron energy spectra, covering the entire energy range of interest, for two standard radionuclide neutron sources ((241)Am-B and (241)Am-F) have been derived from Bonner sphere measurements by using high-resolution a priori data in the unfolding process. In each case, two a priori spectra were used, one from a two-stage calculation and also one from a combination of the calcul...

The Antarctic psychrophilic green alga Chlamy-domonas sp. UWO 241 is an emerging model for studying microbial adaptation to polar environments. However, little is known about its evolutionary history and its phylogenetic relationship with other chlamydomonadalean algae is equivocal. Here, we attempt to clarify the phylogenetic position of UWO 241, specifically with respect to Chlamydomonas rau-...

The existence of 9-variable Boolean functions having nonlinearity strictly greater than 240 has been shown very recently (May 2006) by Kavut, Maitra and Yücel. The functions with nonlinearity 241 have been identified by a heuristic search in the class of Rotation Symmetric Boolean Functions (RSBFs). In this paper we efficiently perform the exhaustive search to enumerate the 9-variable RSBFs hav...

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