نتایج جستجو برای: پروتئین hsp40
تعداد نتایج: 18516 فیلتر نتایج به سال:
A group of cytosolic proteins are targeted to lysosomes for degradation in response to serum withdrawal or prolonged starvation by a process termed chaperone-mediated autophagy. In this proteolytic pathway little is known about how proteins are translocated across lysosomal membranes. We now show that an isoform of the constitutively expressed protein of the heat shock family of 70 kDa (Hsc70) ...
Molecular chaperones from Hsp90 and Hsp70 families are known to bind stably to the mutant p53 tumor suppressor protein, and transiently to the wild-type p53 in cells and in vitro [1, 2]. Using highly purified human recombinant proteins, we reconstituted the in vitro chaperone-dependent reactions of p53 binding to the WAF1 promoter-derived sequence. At the physiological temperature of 37°C, Hsp9...
Hsp70 chaperones assist in a large variety of protein-folding processes in the cell. Crucial for these activities is the regulation of Hsp70 by Hsp40 cochaperones. DnaJ, the bacterial homologue of Hsp40, stimulates ATP hydrolysis by DnaK (Hsp70) and thus mediates capture of substrate protein, but is also known to possess chaperone activity of its own. The first structure of a complete functiona...
In 1990, HSP40 was identified as a novel mammalian heat shock protein with molecular weight of approximately 40 kDa. Subsequent its partial amino acid sequence and cDNA cloning revealed that is homologue bacterial DnaJ protein. It has been found together HSP70 involved in the folding, protection denaturation promotion recovery heat-denatured also jointly inhibit formation aggregates characteris...
Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...
Parkinson's disease (PD) is the second most common devastating neurodegenerative disorder after Alzheimer's disease. The precise molecular and cellular basis underlying PD still remains uncertain; however, accumulating evidence suggests that neuronal cell death is caused by a combination of environmental and genetic factors. Over the previous two decades, more than 20 genes have been identified...
Molecular chaperones of the heat shock protein 70 (Hsp70) variety facilitate protein folding and assembly. They are assisted in this role by their Hsp40 partners, and recent studies have shed new light on how the 'J domains' of these 'cochaperones' activate substrate binding by Hsp70 molecules.
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