The photosensitized hole injection and guanine base damage phenomena have been investigated in the DNA sequence, 5'-d(CATG(1)(Py)CG(2)TCCTAC) with a site-specifically positioned pyrene-like (Py) benzo[a]pyrene 7,8-diol 9,10-epoxide-derived N(2)-guanine adduct (G(1)(Py)). Generation of the Py radical cation and subsequent hole injection into the DNA strand by a 355 nm nanosecond laser pulses (ap...

N-methylpyrrole (Py)-N-methylimidazole (Im) polyamides are small organic molecules that bind to DNA with sequence specificity and can be used as synthetic DNA-binding ligands. In this study, five hairpin eight-ring Py-Im polyamides 1-5 with different number of Im rings were synthesized, and their binding behaviour was investigated with surface plasmon resonance assay. It was found that associat...

Reactions of the lithium salts [{RAl(2-py')3Li·THF] [2-py' = 2-py (2-pyridyl), R = (n)Bu (1), R = (sec)Bu (2); py' = 5-Me-2-py (5-methyl-2-pyridyl), R = Me (3); 6-Me-2-py (6-methyl-2-pyridyl), R = Et (4b)] with the corresponding metal(ii) halides give the new heterobimetallic sandwich compounds [{RAl(2-py)3}2M] [R = (n)Bu, M = Ca (5), Mn (6), Fe (7); R = (sec)Bu, M = Ca (8), Mn (9)], [{MeAl(5-M...

Impermeable seed/fruit coat, i.e. physical dormancy (PY) occurring only in several genera of 18 angiosperm families plays an important role in controlling seed persistence and germination timing. It has been theoretically speculated that PY is more prevalent in drylands than in moist vegetation zones, but unequivocal support for this assertion is currently unavailable. The broad objective of th...

The first examples of Pt complexes of the well known anti-epilepsy drug and histone deacetylase inhibitor, valproic acid (VPA), are reported. Reaction of the Pt(II) am(m)ine precursors trans-[PtCl(2)(NH(3))(py)] and trans-[PtCl(2)(py)(2)] with silver nitrate and subsequently sodium valproate gave trans-[Pt(VPA(-1H))(2)(NH(3))(py)] and trans-[Pt(VPA(-1H))(2)(py)(2)], respectively. The valproato ...

The retinoblastoma tumor suppressor protein (pRb) can associate with the transforming proteins of several DNA tumor viruses, including the large T antigen encoded by polyomavirus (Py T Ag). Although pRb function is critical for regulating progression from G1 to S phase, a role for pRb in S phase has not been demonstrated or excluded. To identify a potential effect of pRb on DNA replication, pRb...

INTRODUCTION The efficacy and safety of tocilizumab in patients with rheumatoid arthritis have been evaluated in a comprehensive phase 3 program. Patients from these randomized trials could receive tocilizumab treatment in open-label extension trials. Here, the long-term safety profile of tocilizumab, using pooled data from all of these trials, is reported. METHODS Cumulative safety data (as ...

Pyridine (PY) effects on rat hepatic cytochromes P450 (CYP) 3A1 and 3A2 expression were examined at the levels of metabolic activity, protein, and mRNA and were compared with those of CYP2B1/2 and CYP2E1. CYP3A metabolic activity as well as CYP3A protein and mRNA levels increased following treatment of rats with PY. CYP3A1 and CYP3A2 were differentially affected by PY treatment in terms of indu...