OBJECTIVE The goal of our study was to identify the regulatory mechanisms of gene expression mediated by miRNAs and DNA methylation in colon adenocarcinoma (COAD). MATERIALS AND METHODS   The miRNAs and mRNAs expression and DNA methylation data of COAD and adjacent normal tissues were obtained from The Cancer Genome Atlas (TCGA) database. Based on the differentially expressed miRNAs and mRNAs...

The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central-South University (Changsha, Hunan, China) between January and December 2012 were selected. Gastric cancer cells were obtained for RNA extraction, and miRNAs were detected ...

We report new Ks-band secondary eclipse observations for the hot-Jupiters WASP-19b and WASP-43b. Using the IRIS2 infrared camera on the Anglo-Australian Telescope (AAT), we measured significant secondary eclipses for both planets, with depths of 0.287+0.020 −0.020 per cent and 0.181+0.027 −0.027 per cent for WASP-19b and WASP-43b, respectively. We compare the observations to atmosphere models f...

ABSTRACT We present a study of photochemical hazes exoplanet atmospheres based on self-consistent model including haze microphysics, disequilibrium chemistry, and radiative feedbacks. derive the properties required to match Hubble Space Telescope observations 10 hot-Jupiters. HAT-P-12b, HD-189733b, HD-209458b, WASP-6b require mass fluxes between 5 × 10?15 9 10?12 g cm?2 s?1 observations. WASP-1...

1. Institute of Veterinary Physiology, Free University of Berlin, Oertzenweg 19b , 14163 6 Berlin, Germany 7 2. Department of Physiology, Faculty of Veterinary Sciences, University of Khartoum, Sudan 8 3. University of Veterinary & Animal Sciences Lahore, Pakistan 9 10 Running head: Modulation of urea transport 11 12 Author for correspondence: 13 H. Martens 14 Department of Veterinary Physiolog...

We have examined serum microRNA expression in multiple myeloma (MM) patients at diagnosis and at complete response (CR) after autologous stem-cell transplantation (ASCT), in patients with stable monoclonal gammopathy of undetermined significance, and in healthy controls. MicroRNAs were first profiled using TaqMan Human MicroRNA Arrays. Differentially expressed microRNAs were then validated by i...

Penetration, development, and reproduction of a virulent 'Harmony' population of Meloidogyne arenaria was studied on two nematode-resistant grape rootstocks 10-17A and 6-19B. 'Cabernet Sauvignon' was used as a susceptible control for comparison. Plants were inoculated with 100 freshly hatched second-stage juveniles (J2) of M. arenaria. Greater numbers of J2 penetrated roots of 'Cabernet' than 1...

PURPOSE The aim of the present study was to assess the expression of miRNAs in the Vitreous Humor (VH) of patients with Macular Hole (MH) and Epiretinal Membrane (ERM) compared to a control group. METHODS In this prospective, comparative study, 2-ml of VH was extracted from the core of the vitreous chamber in consecutive patients who underwent standard vitrectomy for ERM and MH. RNA was extra...

Micro RNAs (miRNAs) are small non-coding RNAs, which dampen gene expression by repressing translation and/or inducing degradation of target-mRNAs. Although the role of miR-17-19b (a truncated version of miR-17-92 cluster) is well documented in MYC-driven B cell lymphomagenesis, little is known about the function of the cluster in the maintenance of full-blown lymphomas. We employed SILAC-based ...

Fine-tuning of inflammatory responses by microRNAs (miRNAs) is complex, as they can both enhance and repress expression of pro-inflammatory mediators. In this study, we investigate inflammatory responses following global miRNA depletion, to better define the overall contribution of miRNAs to inflammation. We demonstrate that miRNAs positively regulate Toll-like receptor signaling using inducibl...