Biacetyl reacts with oxone to give bis-dioxirane [3,3'-dimethyl-3,3'-bidioxirane, 3B] and mono-dioxirane [1-(3-methyl-dioxiran-3-yl)ethanone, 3A)]. Bis-dioxirane 3B is formed when two oxygens are incorporated into biacetyl, while mono-dioxirane 3A incorporated only one. A greater stability is observed in 3B compared to 3A, which is attributed to an alpha-dioxiranyl (anomeric) effect in the form...

BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishm...

Six lines and five testers were crossed in line x tester fashion and the F1s were evaluated under coastal saline situation. The ratio between the estimates of additive and dominance variances indicated preponderance of nonadditive gene action for the characters namely, plant height, number of productive tillers, boot leaf length, panicle length, grain weight per primary panicle and grain yield ...

Microelectrodes were used to record from somatosensory areas 3b and adjoining areas 3a and 1 in newborn monkeys. At birth, area 3b was responsive to cutaneous stimuli and had an adult-like somatotopic organization in marmosets and one squirrel monkey, while areas 1 and 3a had only limited responsiveness. In newborn macaque monkeys, cortex was unresponsive to cutaneous stimuli; however, by 1 mon...

Mammalian Ste20-like proline/alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinases phosphorylate and regulate cation-coupled Cl(-) cotransporter activity in response to cell volume changes. SPAK and OSR1 are activated via phosphorylation by upstream with-no-lysine (WNK) kinases. In Caenorhabditis elegans, the SPAK/OSR1 ortholog germinal center kinase (GCK)-3 binds to and r...

The synthesis and characterization of EtOSHPh2PNCH2CHjh(HNCH2CH21N (ethoxy·N,N'·bis(di. phenylphosphinolazasilatrane, the title compound 3b) is reporud. ts reactions with sulfur and Mel proceed easily via quaternization at the phosphorus sites to give the bis(phosphonium) salt and the bis(phosphlne) sulfide, respectively. Synthesis and characterization of the coordination compounds (3b)Ni(COh, ...

AMP-activated protein kinase (AMPK), the key sensor and regulator of cellular energy status, is a heterotrimeric enzyme with multiple isoforms for each subunit (α1/α 2; β1/β2; γ1/γ2/γ3). Mutations in PRKAG2, which encodes the γ2 regulatory subunit, cause a cardiomyopathy characterized by hypertrophy and conduction abnormalities. The two reported PRKAG2 transcript variants, γ2-short and γ2-long ...

Myeloid cell lines that have achieved leukemic transformation may also have acquired the ability to produce hematopoietic growth factors. In certain instances, neutralizing antibodies directed against the growth factor have inhibited growth, supporting an autocrine mechanism in their transformation. The effect of anti-receptor antibodies on their growth and transformed phenotype has not been re...