Portal hypertension (PHT) is a common complication of liver cirrhosis and significantly increases morbidity and mortality. Abrogation of PHT using NSAIDs has demonstrated that prostacyclin (PGI(2)), a direct downstream metabolic product of cyclooxygenase (COX) activity, is an important mediator in the development of experimental and clinical PHT. However, the role of COX isoforms in PGI(2) bios...

Several indications exist that prostacyclin (PGI(2)) release in the cardiovascular system might be affected by cyclooxygenase (COX)-2-specific inhibitors. This could reflect an inhibition of PGI(2) synthesis in the endothelium although in these cells mainly COX-1 is expressed. Inflammation and stress induce COX-2 in smooth muscle cells which could have happened in patients with cardiac diseases...

The patient-generated index (PGI) is a more novel approach to evaluating health-related quality of life (HRQOL) that allows patients to formulate their own responses in an open-ended format in order to measure HRQOL based on each patient's own stated goals and expectations. To date the use of PGI in the setting of patients diagnosed with cancer remains relatively less common compared to other h...

One-step enzyme purification and immobilization were developed based on simple adsorption of a family 3 cellulose-binding module (CBM)-tagged protein on the external surface of high-capacity regenerated amorphous cellulose (RAC). An open reading frame (ORF) Cthe0217 encoding a putative phosphoglucose isomerase (PGI, EC 5.3.1.9) from a thermophilic bacterium Clostridium thermocellum was cloned a...

Parking Guidance and Information (PGI) signs are thought to enable a more efficient use of the available parking stock. Despite the installation of PGI systems in many cities and their operation for a number of years, there is a lack of reliable evidence of the size of the benefits that these systems can achieve. This paper describes the development of driver parking choice models (both during ...

Eastern Sierra Nevada populations of the willow beetle Chrysomela aeneicollis commonly experience stressfully high and low environmental temperatures that may influence survival and reproduction. Allele frequencies at the enzyme locus phosphoglucose isomerase (PGI) vary across a climatic latitudinal gradient in these populations, with PGI allele 1 being most common in cooler regions and PGI all...

BACKGROUND Prostaglandin I(2) (PGI(2)), a lipid mediator currently used in treatment of human disease, is a critical regulator of adaptive immune responses. Although PGI(2) signaling suppressed Th1 and Th2 immune responses, the role of PGI(2) in Th17 differentiation is not known. METHODOLOGY/PRINCIPAL FINDINGS In mouse CD4(+)CD62L(+) naïve T cell culture, the PGI(2) analogs iloprost and cicap...

PGI(2) plays a key role in limiting Th2-mediated airway inflammation. In studies to investigate the mechanism underlying such regulation, we found that the PGI(2) receptor, IP, is preferentially expressed by effector CD4(+) Th2 cells, when compared with Th1 cells. Adoptive transfer of DO11.10 Th2 cells pretreated with PGI(2) resulted in considerably attenuated pulmonary inflammation and airway ...

The nucleus paragigantocellularis (PGI) is located in the rostral ventrolateral medulla and has noticeable connections with some other brain nuclei, such as locus ceruleus, nucleus raphe magnus and periaqueductal gray. In rats it is 3 mm in rostrocaudal and 1 mm in mediolateral and 1 mm in the dorsolateral aspect. Anatomically and functionally, PGI has been divided into two subnuclei, retrofaci...

Electrophoretic expression of 20 enzymes coded by a minimum of 30 gene loci is reported for sea lamprey. ADA, ADH. AGP, AAT, CPK, G6PDH, GAPDH, LDH. MDH, PEP, 6PCD, PGI, PGK, PGM, PK, PMI, and SDH yielded gel resolution satisfactory for use in future population studies. Six loci, AGP, !LZDH-1, PGI-I, PGI-2, PGi%f-l, and PlMI were polymorphic. Enzyme expresion did not vary between life stages (a...