Brain-derived neurotrophic factor (BDNF) exerts multiple biological functions in the CNS. Although BDNF can control transcription and protein synthesis, it still remains open to question whether BDNF regulates lipid biosynthesis. Here we show that BDNF elicits cholesterol biosynthesis in cultured cortical and hippocampal neurons. Importantly, BDNF elicited cholesterol synthesis in neurons, but ...

After peripheral nerve injury, neurotrophins play a key role in the regeneration of damaged axons that can be augmented by exercise, although the distinct roles played by neurons and Schwann cells are unclear. In this study, we evaluated the requirement for the neurotrophin, brain-derived neurotrophic factor (BDNF), in neurons and Schwann cells for the regeneration of peripheral axons after inj...

introduction: it has shown that listening to mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. a few studies have reported the effects of prenatal plus postpartum exposure of mice to the mozart music on brain-drived neurotrophic factor (bdnf) in the hippocampus. here we investigated the effect of postpartum exposure to the mozart music on bdnf ...

OBJECTIVE The subgenual anterior cingulate cortex is implicated in the pathology and treatment response of major depressive disorder. Low levels of brain-derived neurotrophic factor (BDNF) and reduced markers for GABA function, including in the amygdala, are reported in major depression, but their contribution to subgenual anterior cingulate cortex dysfunction is not known. METHOD Using polym...

Growing axons during development are guided to their targets by the activity of their growth cones. Growth cones integrate positive and negative guidance cues in deciding the direction in which to extend. We demonstrated previously that treatment of embryonic retinal ganglion cells with brain-derived neurotrophic factor (BDNF) protects their growth cones from collapse induced by nitric oxide (N...

Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB), play a critical role in memory extinction. However, the detailed role of BDNF in memory extinction on the basis of neural circuit has not been fully understood. Here, we aim to investigate the role of BDNF signaling circuit in mediating conditioned taste aversion (CTA) memory extinction of t...

Moods and metabolism modulate each other. High comorbidity of depression metabolic disorders, such as diabetes obesity, poses a great challenge to treat conditions. Here we report the therapeutic efficacy brain-derived neurotrophic factor (BDNF) by gene transfer in dorsal raphe nucleus (DRN) chronic unpredictable mild stress model (CUMS) models obesity. In CUMS, BDNF-expressing mice displayed a...

Brain-derived neurotrophic factor (BDNF) is a neurotrophin presented widely in central nervous system (CNS). The general function of BDNF in CNS is maintaining neuronal viability in ischemic condition, as well as providing neuronal plasticity and modulating behavioral activity. BDNF regulates axonal growth and differentiation of neurons; synapse formation; activity of dopaminergic, serotoninerg...

Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and examined the association of the Val66Met B...