Item Response Theory (IRT) evaluates, on the same scale, examinees who take different tests. It requires linkage of examinees’ ability scores as estimated from However, IRT techniques assume independently random sampling abilities a standard normal distribution. Because this assumption, not only much labor to design, but it also has no guarantee optimality. To resolve that shortcoming, study pr...

Assessment of socially unacceptable behaviors and attitudes via self-report is likely to yield skewed data that may be vulnerable to measurement non-invariance. Item response theory (IRT) can help address these measurement challenges. This paper illustrates application of IRT to data from a teen dating violence intervention study. Three factors reflecting teens’ attitudes about dating violence ...

Multiple reaction monitoring (MRM) has recently become the method of choice for targeted quantitative measurement of proteins using mass spectrometry. The method, however, is limited in the number of peptides that can be measured in one run. This number can be markedly increased by scheduling the acquisition if the accurate retention time (RT) of each peptide is known. Here we present iRT, an e...

1 Abstract Item response theory (IRT) has arguably been one of the most successful and widely used statistical modeling techniques in psychometrics, with applications in developmental, social, educational and cognitive psychology for example, as well as in medical research, demography and other social science settings. In this paper I will try to briefly summarize some of the important research...

Interferon-gamma (IFN-gamma) inhibits proliferation of vascular smooth muscle cells (VSMCs) in culture and reduces arterial restenosis post-balloon angioplasty. The identification and characterization of IFN-gamma-specific transcripts in VSMCs are an important approach to discern the molecular mechanisms underlying vascular proliferative disease. In this report, we describe IRT-1, a novel mRNA ...

Item response theory (IRT) has become one of the most popular scoring frameworks for measurement data. IRT models are used frequently in computerized adaptive testing, cognitively diagnostic assessment, and test equating. This article reviews two of the most popular software packages for IRT model estimation, BILOG-MG (Zimowski, Muraki, Mislevy, & Bock, 1996) and MULTILOG (Thissen, 1991), which...

Circulating immunoreactive trypsinogen (IRT), a biomarker of exocrine pancreatic disease in cystic fibrosis (CF), is elevated in most CF newborns. In those with severe CF transmembrane conductance regulator (CFTR) genotypes, IRT declines rapidly in the first years of life, reflecting progressive pancreatic damage. Consistent with this progression, a less elevated newborn IRT measure would refle...

The isovolumetric relaxation time of the left ventricle (IRT) in 20 hypothyroid patients (133 +/- (SE of mean) 4 ms) was significantly longer than that in 23 normal subjects (95 +/- 3 ms). During a trial of thyroxine replacement the IRT in 12 hypothyroid patients fell from 143 +/- 4 ms to 107 +/- 4 ms. The IRT seems to be a useful index of end-organ function in hypothyroidism.