Prothrombin (PT) is a target for antibodies with lupus anticoagulant (LA) activity. Anti-prothrombin antibodies (aPT) were recently identified as antibodies directed toward a phospholipid-binding protein. aPT are a new serologic marker of antiphospholipid syndrome. The objective was to detect aPT in a group of 46 patients with acute ischemic stroke in order to correlate their presence with clin...

Children's affective perspective-taking (APT) may provide a basis for efficient social interaction. The APT abilities of 83 children from 46 same-sex sibling pairs (ages 36 to 72 months, M = 52.8; SD = 12.6) were assessed through their reactions to affectively loaded story situations, and children whose APT ability (but not general cognitive abilities) was low relative to other children of thei...

recently, specific attention has been paid to aptamers, short dna or rna, as a tool for cancer diagnosis and therapy. in the present study mcs nanogels were prepared by myristate: chitosan at 1:9 ratio and were characterized by several techniques. a selected ssdna aptamer(apt) capable of detecting lncap cells was linked to myristilated chitosan nanogels (apt-mcs) by glutaraldehyde and loaded wi...

Oncogenic NRAS mutations are frequent in melanoma and lead to increased downstream signaling and uncontrolled cell proliferation. Since the direct inhibition of NRAS is not possible yet, modulators of NRAS posttranslational modifications have become an area of interest. Specifically, interfering with NRAS posttranslational palmitoylation/depalmitoylation cycle could disturb proper NRAS localiza...

BACKGROUND AND PURPOSE Although the use of antiplatelet therapy (APT) is associated with the risk of intracerebral hemorrhage (ICH), there are limited data on prestroke APT and outcomes, particularly among patients on combination APT (CAPT). We hypothesized that the previous use of antiplatelet agents is associated with increased mortality in ICH. METHODS We analyzed data of 82 576 patients w...