Cryopyrin-associated periodic syndrome (CAPS) is caused by gain-of-function NLRP3 mutations. Recently, somatic NLRP3 mosaicism has been reported in some CAPS patients who were previously classified as "mutation-negative." We describe here the clinical and laboratory findings in eight British adult patients who presented with symptoms typical of CAPS other than an onset in mid-late adulthood. Al...

Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by heterozygous mutations of NLRP3 gene. CAPS consists of three phenotypically similar but distinct syndromes: familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and CINCA syndrome. Among them, FCAS shows the mildest phenotype while CINCA is the severest. Common symptoms include sporadic or c...

Thi s a r t i c l e addres se s the p rob l em o f va lu ing Amer i can ca l l op t i ons w i th caps on d i v idendpaying assets . Since early exercise is al lowed, the valuat ion problem requires the determinat ion of opt imal exercise pol icies . Options with two t ypes o f caps a re ana ly zed cons tan t caps and caps with a constant growth rate. For constant caps, it is optimal to exercise...

Streptococcus pneumoniae causes serious infections in children, the elderly, and immunocompromised patients. Protection against infections with S. pneumoniae is mediated through Abs against the capsular polysaccharides (caps-PS). We previously showed that the murine Ab response to caps-PS is dependent on CD40-CD40L interaction. In the present paper, we addressed the question of whether the CD40...

Objective Capsaicinoids (CAPs), most commonly found in chili peppers, have a multitude of pharmacological and physiological effects, such as anti-inflammation, antioxidant, and anticancer effects. In the present study, we set out to investigate the hypothesis that CAPs mitigate obesity in rats and the possible mechanisms thereof. Materials and methods Rats were divided into six groups, includ...

The cost of political campaigns in the U.S. has risen substantially in recent years. For example, real spending on congressional election campaigns doubled between 1976 and 1992 (Steven D. Levitt [1995]). There are many reasons why increased campaign spending might be socially harmful. First, increased spending means increased fund-raising, which may keep politicians from their legislative duti...

With aspect-oriented programming techniques, modularity may be achieved via separating cross-cutting concerns. Data provenance can be considered as a crosscutting concern: code for collecting provenance data is usually scattered across various places in a software system. Aspect-oriented programming allows to seamlessly integrate cross-cutting concerns into existing software applications withou...

Background Local initiatives to reduce alcohol harms are common. One UK approach, Community Alcohol Partnerships (CAPs), involves partnerships between the alcohol industry and local government, focussing on alcohol misuse and anti-social behaviour (ASB) among young people. This study aimed to assess the evidence of effectiveness of CAPs. Methods We searched CAP websites and documents, and dat...

Some new families of caps in Galois affine spaces AG(N , q) of dimension N ≡ 0 (mod 4) and odd order q are constructed. Such caps are proven to be complete by using some new ideas depending on the concept of a regular point with respect to a complete plane arc. As a corollary, an improvement on the currently known upper bounds on the size of the smallest complete caps in AG(N , q) is obtained.