نتایج جستجو برای: نروتروفین bdnf

تعداد نتایج: 8999  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
G J Michael S Averill A Nitkunan M Rattray D L Bennett Q Yan J V Priestley

Using immunocytochemistry and in situ hybridization, we have examined the expression of brain-derived neurotrophic factor (BDNF) and of neurotrophin receptors in dorsal root ganglion cells. In the adult rat, BDNF mRNA and protein were found mainly in the subpopulation of cells that express the nerve growth factor (NGF) receptor trkA and the neuropeptide calcitonin gene-related peptide (CGRP). N...

Journal: :Investigative ophthalmology & visual science 2007
Daniel M Paskowitz Kate M Donohue-Rolfe Haidong Yang Douglas Yasumura Michael T Matthes Kamran Hosseini Carolyn M Graybeal George Nune Marco A Zarbin Matthew M Lavail Jacque L Duncan

PURPOSE A prior study showed that brain-derived neurotrophic factor (BDNF) rescues photoreceptors from collateral retinal damage caused by photodynamic therapy (PDT). This study was conducted to determine whether ciliary neurotrophic factor (CNTF), a combination of BDNF and CNTF, or pigment epithelial cell-derived growth factor (PEDF) might protect photoreceptors and retinal function more effec...

Journal: :Molecular and cellular endocrinology 2010
Erich N Ottem Jessica E Poort Hongbing Wang Cynthia L Jordan S Marc Breedlove

Castration of adult male rats causes dendrites of the spinal nucleus of the bulbocavernosus (SNB) to retract. The neurotrophin brain-derived neurotrophic factor (BDNF) is implicated in mediating these androgenic effects on SNB dendrites. We previously found that castration decreases BDNF mRNA in SNB somata and BDNF protein in proximal SNB dendrites, effects not observed in nearby retrodorsolate...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Kambiz Mousavi Bernard J Jasmin

In skeletal muscle, brain-derived neurotrophic factor (BDNF) has long been thought to serve as a retrograde trophic factor for innervating motor neurons throughout their lifespan. However, its localization in mature muscle fibers has remained elusive. Given the postulated roles of BDNF in skeletal muscle, we performed a series of complementary experiments aimed at defining the localization of B...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
J M Conner J C Lauterborn Q Yan C M Gall S Varon

A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature ra...

2017
Pengzhou Hang Jing Zhao Li Sun Minghui Li Yu Han Zhimin Du Yue Li

The clinical application of doxorubicin (Dox) is limited by its adverse effect of cardiotoxicity. Previous studies have suggested the cardioprotective effect of brain-derived neurotrophic factor (BDNF). We hypothesize that BDNF could protect against Dox-induced cardiotoxicity. Sprague Dawley rats were injected with Dox (2.5 mg/kg, 3 times/week, i.p.), in the presence or absence of recombinant B...

Journal: :Thorax 2005
R Staats P Stoll D Zingler J C Virchow M Lommatzsch

BACKGROUND Patients with obstructive sleep apnoea syndrome (OSAS) often display persistent cognitive dysfunction despite effective treatment with continuous positive airway pressure (CPAP). Brain-derived neurotrophic factor (BDNF) is a key mediator of memory and cognition, but its regulation in OSAS and during CPAP treatment is unknown. METHODS Serum and plasma BDNF concentrations, BDNF secre...

Journal: :Genes, brain, and behavior 2007
J M Mercader M Ribasés M Gratacòs J R González M Bayés R de Cid A Badía F Fernández-Aranda X Estivill

Murine models and association studies in eating disorder (ED) patients have shown a role for the brain-derived neurotrophic factor (BDNF) in eating behavior. Some studies have shown association of BDNF -270C/T single-nucleotide polymorphism (SNP) with bulimia nervosa (BN), while BDNF Val66Met variant has been shown to be associated with both BN and anorexia nervosa (AN). To further test the rol...

Journal: :Brain research. Molecular brain research 2004
Malini Sathanoori Brian G Dias Amrita R Nair Sunayana B Banerjee Shubha Tole Vidita A Vaidya

Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampus, where it has been implicated in physiological functions such as the modulation of synaptic strength as well as in the pathophysiology of epileptic seizures. BDNF expression is highly regulated and the BDNF gene can generate multiple transcript isoforms by alternate splicing of four 5' exons (exons I-IV) to ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Barbara Lom Jeffrey Cogen Analiza Lontok Sanchez Thuy Vu Susana Cohen-Cory

The dendritic and axonal arbors of developing retinal ganglion cells (RGCs) are exposed to two sources of BDNF: RGC dendrites are exposed to BDNF locally within the retina, and RGC axons are exposed to BDNF at the target, the optic tectum. Our previous studies demonstrated that increasing tectal BDNF levels promotes RGC axon terminal arborization, whereas increasing retinal BDNF levels inhibits...

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