BACKGROUND AND OBJECTIVE Clostridium difficile infection (CDI) is associated with high management costs, particularly in recurrent cases. Fidaxomicin treatment results in lower recurrence rates than vancomycin and metronidazole, but has higher acquisition costs in Europe and the USA. This systematic literature review summarises economic evaluations (EEs) of fidaxomicin, vancomycin and metronida...

A chieving a secure, sustainable energy future is one of the greatest scientific and societal challenges of our time. Electrical energy storage (EES) plays a vital role in daily life because of our dependence on numerous electronic devices that require mobility. There is also a need for large-scale and inexpensive EES for grid and transportation applications. Electricity generated from renewabl...

Extra Osseous Ewing's Sarcoma (EES) has been considered a distinct clinicopathological entity despite its striking ultrastructural similarity to Ewing's Sarcoma of Bone (ESB) and same translocation involving band ql2 of chromosome 22(1,2) Today more than 150 cases of EES in different locations have been described, for example, larynx, scalp, nasal fossa, neck, chest wall, lung, perineum, finger...

Purpose This study contributes to a better understanding of the important actor-specific, micro-level legitimacy dimensions in dynamic entrepreneurial ecosystems (EEs). Design/methodology/approach Using an embedded case approach and rich longitudinal data collected over 16 years within French EE, analyzes gaining process two actors coming from opposite founding conditions. Findings Three (3L) a...

Infant powdered milk (i.e., infant formula) is a rich and convenient source of nutrients, substituting for human breast milk in many countries. Moreover, it is the basic foodstuff for the infants because of its minerals and proteins, which are essential for their growth and development. However, there are still limited data on radioactivity levels in infant powdered milk around the world, inclu...

AIMS Newer-generation everolimus-eluting stents (EES) have been shown to improve clinical outcomes compared with early-generation sirolimus-eluting (SES) and paclitaxel-eluting stents (PES) in patients undergoing percutaneous coronary intervention (PCI). Whether this benefit is maintained among patients with saphenous vein graft (SVG) disease remains controversial. METHODS AND RESULTS We asse...

The putative role of sorting early endosomes (EEs) in synaptic-like microvesicle (SLMV) formation in the neuroendocrine PC12 cell line was investigated by quantitative immunoelectron microscopy. By BSA-gold internalization kinetics, four distinct endosomal subcompartments were distinguished: primary endocytic vesicles, EEs, late endosomes, and lysosomes. As in other cells, EEs consisted of vacu...

Ishihara, Satoshi, John A. Ward, Osamu Tasaki, Basil A. Pruitt, Jr., Martine A. Javors, Richard A. Cassidy and David W. Mozingo. Biphasic changes in left ventricular function during hyperdynamic endotoxemia. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1516– R1524, 1999.—Cardiac contractility was studied in a clinically relevant conscious swine model simulating human hemodyn...

Chiral ruthenium(II)-salen complexes [RuII(salen)(PPh3)2] catalyse asymmetric aziridination of alkenes with up to 83% ees, asymmetric amidation of silyl enol ethers with up to 97% ees, and allylic amidation of cholesteryl acetates with good regioselectivity.