Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifuncti...

The membrane disruption properties of high generation (G4 to G7) poly(amidoamine) (PAMAM) dendrimers are evaluated and compared to linear poly(lysine). The G6 and G7 dendrimers are unusually effective at inducing leaky fusion of anionic, large unilamellar vesicles, as determined by standard fluorescence assays for lipid mixing, leakage, and contents mixing. Both G7 dendrimer and poly(lysine) ar...

Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r₁) values about four times higher than that of clinically used Gd-DTPA (Magnevist(®), Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrim...

the purpose of the matching interdiction problem in a weighted graph is to findtwo vertices such that the weight of the maximum matching in the graph withoutthese vertices is minimized. an approximate solution for this problem has beenpresented. in this paper, we consider dendrimers as graphs such that the weightsof edges are the bond lengths. we obtain the maximum matching in some types ofdend...

The galactose specific lectin LecA partly mediates the formation of antibiotic resistant biofilms by Pseudomonas aeruginosa, an opportunistic pathogen causing lethal airways infections in immunocompromised and cystic fibrosis patients, suggesting that preventing LecA binding to natural saccharides might provide new opportunities for treatment. Here 8-fold (G3) and 16-fold (G4) galactosylated an...

Here, we show that Au nanoparticles having diameters of less than 2.2 nm can be extracted from within the interior of PAMAM dendrimers using n-alkanethiol extractants. Extraction proceeds quickly, regardless of the size of the nanoparticle, the dendrimer generation, or the peripheral functionalization of the dendrimer. The extraction rate is fastest for the lowest generation dendrimers, the sma...

In this study, the host-guest behavior of poly(amidoamine) (PAMAM) dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO) derivatives were used as paramagnetic guest molecules. The results showed that TEMPO-COOH significantly broaden the ¹H NMR peaks of amine- and hydroxyl-terminated PAM...

Capecitabine, an effective anticancer drug in colorectal cancer chemotherapy, may create adverse side effects on healthy tissues. In the present study, we first induced colon adenocarcinoma with azoxymethane, a carcinogen agent, and then investigated the potentiality of polyamidoamine (PAMAM) dendrimer to improve capecitabine therapeutic index and decrease its adverse side effects on healthy ti...

Protein expression monitoring can be a good tool to determine disease onset and progression, and is also used in drug discovery and investigational science (1–4). However, commonly used assays lack the sensitivity and specificity required for the detection of low-abundance proteins (5,6). Several signal amplification technologies have been designed and applied to protein detection assays, inclu...