To analyse the influence of the sex of the transmitting grandparents on the occurrence of the congenital form of myotonic dystrophy (CDM), we have studied complete three generation pedigrees of 49 CDM cases, analysing: (1) the sex distribution in the grandparents' generation, and (2) the intergenerational amplification of the CTG repeat, measured in its absolute and relative values, between gra...

BACKGROUND The unique structure and coding of the Clinical Practice Research Datalink (CPRD) presents challenges for epidemiologic analysis and for comparisons with other databases. To address this limitation we sought to transform CPRD into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). METHODS An extraction, transformation and loading process was developed, w...

This study analyzed nurses' perceptions of clinical decision making (CDM) in their clinical practice and compared differences in decision making related to nurse demographic and contextual variables. A cross-sectional survey was carried out with 2095 nurses in four hospitals in Norway. A 24-item Nursing Decision Making Instrument based on cognitive continuum theory was used to explore how nurse...

Central difference method (CDM) that is explicit for pseudo dynamic testing is also supposed to be explicit for real-time substructure testing (RST). However, to obtain correct velocity dependent restoring force of the physical substructure being tested, the target velocity is required to be calculated as well as displacement. The standard CDM provides only explicit target displacement but not ...

Among three chip-level electrostatic discharge (ESD) test standards, which were human-body model (HBM), machine model (MM), and charged-device model (CDM), the CDM ESD events became critical due to the larger and faster discharging currents. Besides input/output (I/O) circuits which were connected to I/O pads, core circuits also suffered from CDM ESD events caused by coupled currents between I/...

BACKGROUND Chronic disease is responsible for 80% of the burden of disease in Australia. The Australian Government Medicare Benefits Schedule (MBS) provides incentives through specific Medicare items to optimise chronic disease management (CDM), yet little is known about factors that influence their uptake. METHODS Exploratory qualitative research was used, which incorporated focus groups and...

The Cold Dark Matter (CDM) model has an elegant simplicitly which makes it very predictive, but when its parameters are xed at their`canonical' values its predictions are in connict with observational data. There is, however, much leeway in the initial conditions within the CDM framework. We advocate a re-examination of the CDM model, taking into account modest variation of parameters from thei...

Clean Development Mechanism (CDM) is defined as one of the “flexibility” mechanisms that allows entities based in Developed Countries (Annex I Parties) to develop emission-reducing projects in Developing Countries (non-Annex I Parties), and generate tradable carbon credits corresponding to the volume of carbon emission reductions achieved by those projects. CDM projects have been developed in s...

BACKGROUND Adoption of a common data model across health systems is a key infrastructure requirement to allow large scale distributed comparative effectiveness analyses. There are a growing number of common data models (CDM), such as Mini-Sentinel, and the Observational Medical Outcomes Partnership (OMOP) CDMs. OBJECTIVES In this case study, we describe the challenges and opportunities of a s...