XENOGRAFfTUMORS have indefinite survival when transplanted into atbymic nude rats or mice. However, nude rats reject vascularized hamster cardiac xenografts in tempo (3 to 4 days) similar to that of immunocompetent rats.13 This "slow-motion" hyperacute rejection witnessed in the nude rat is thought to be mediated by a T cell-independent, but antibodyand complement-dependent mechanism(s ).1 In t...
