PURPOSE A substantial proportion of patients with colorectal cancer (CRC) present with iron deficiency anemia (IDA), and fecal immunochemical test (FIT) has proven to be an effective method for detecting the majority of CRC cases. A combination strategy of FIT results and IDA may be useful for risk stratification for detecting advanced colorectal neoplasia (ACRN). We compared the prevalence of ...

UNLABELLED Reactive gliosis involving activation and proliferation of astrocytes and microglia, is a widespread but largely complex and graded glial response to brain injury. Astroglial population has a previously underestimated high heterogeneity with cells differing in their morphology, gene expression profile, and response to injury. Here, we identified a subset of reactive astrocytes isolat...

We present the following results about IDA* and related algorithms: We show that IDA* is not asymptotically optimal in all of the cases where it was thought to be so. In particular, there are trees satisfying all of the conditions previously thought to guarantee asymptotic optimality for IDA*, such that IDA* will expand more than O(N) nodes, where N is the number of nodes eligible for expansion...

Abscission is a developmental process that enables plants to shed unwanted organs. In Arabidopsis, the floral organ abscission is regulated by a signaling pathway consisting of the peptide ligand IDA, the receptor-like kinases (RLKs) HAE and HSL2, and a downstream MAP kinase (MAPK) cascade. However, little is known about the molecular link between ligand-receptor pairs and intracellular signali...

Inflammation can lead to malabsorption of important micronutrients such as iron. Malabsorption and nutritional deficiency can be caused by a variety of pathological and environmental factors causing a range of other symptoms commonly caused by both H. pylori infection and coeliac disease (CD). National guidelines suggest the routine taking of duodenal biopsies to exclude CD when investigating p...

Cristina Maria Areias, Benedita Sampaio-Maia, Hercilia Guimaraes, Paulo Melo, David Andrade I Odontopediatrics, Faculdade de Medicina Dentária da Universidade do Porto, Porto, PT. II Microbiology, Faculdade de Medicina Dentária da Universidade do Porto, Porto, PT. III Pediatrics, Faculdade de Medicina Universidade do Porto, Porto, PT. IV Dentistry, Faculdade de Medicina Dentária da Universidade...

Plants constantly renew during their life cycle and thus require to shed senescent and damaged organs. Floral abscission is controlled by the leucine-rich repeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA. It is unknown how expression of IDA in the abscission zone leads to HAESA activation. Here we show that IDA is sensed directly by the HAESA ectodomain. Crystal structures of H...

Background: Iron deficiency, is a common worldwide complication, especially in preschool children. Iron deficiency anemia (IDA) is associated with changes in the mental and motor development, defects of immune system, cardiovascular, diseases and disruption of lipid profile. In IDA, the occurrence of dyslipidemia is controversial. We aimed to investigate the association between IDA and serum li...

Iron deficiency anemia (IDA) is the most common cause of anemia in the United States, and it particularly affects women of child-bearing age and black, non-Hispanic race/ethnicity. During the surveillance period there were 10,157 incident ("new") cases of IDA among active component service members; the overall incidence rate was 7.1 per 10,000 person-years. The annual incidence rates increased...