We hypothesized that a redox-sensitive transcription factor, redox factor-1 (Ref-1) (HAP1, APE, and APEX), was critical in the regulation of endothelial cell survival in response to hypoxia and cytokines, including tumor necrosis factor (TNF)-alpha. Hypoxia resulted in a significant decrease in Ref-1 protein expression in both human umbilical vein endothelial cells and calf pulmonary artery end...

The ref(2)P gene of Drosophila melanogaster has two common alleles, ref(2)Po which permits the infection of flies by the rhabdovirus sigma (sigma), and ref(2)Pp which is restrictive for sigma infection. This gene has been cloned by P element tagging and shown to code for two RNAs in adult flies. These RNAs are expressed in both males and females, but only the larger is expressed in ovaries. Bot...

We previously reported that glial cell line-derived neurotropic factor (GDNF) receptor alpha1 (GFRalpha1) is a direct target of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1). In the present study, we further analyzed the physiological roles of Ape1/Ref-1-induced GFRalpha1 expression in Neuro2a mouse neuroblastoma cells. Ape1/Ref-1 expression caused the clustering of GFRalpha1 immunoreactivi...

The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain. When TAP binds a REF:RNA complex, it triggers transfer of the RNA from REF to TAP. Here, we have examined the effects of arginine methylation on the activities of the REF protein in mRNA export. We have mapped the arginine methylation sites of REF using mass spectrometry and f...

شرایط افروزش و اشتعال سوخت‌های گداخت هسته‌ای در حضور ناخالص­‌ها، یکی از موارد مهمی است که طراحی قرص‌های سوخت باید مورد توجه قرار گیرد. این مقاله اثر ناخالصی هسته سنگین طلا بر کلیه فرایندهای احتراق پلاسمای غیرتعادلی دوتریم- تریتیم مدل چهار دمایی آن شکل تابع توزیع انرژی رفتار فوتون‌ها تأثیر می‌گذارد بررسی گرفته است. مطالعه شامل اثرات منفی سوخت، طول زمان تشکیل لکه داغ نتایج محاسبات عددی به­ دست آم...

CE/SC : 21, Publié/Published : 1968, Session paper, Ref. No. : 21-00, Special Report for Group 21. CE/SC : 21, Publié/Published : 1968, Session paper, Ref. No. : 21-06, Some Observations upon Distributions of Partial Discharge Pulses Measured with a Multi-Channel Analyser. CE/SC : 21, Publié/Published : 1968, Session paper, Ref. No. : 21-05, 200 kV D.C. Submarine Cable Interconnection between S...

In Hevea brasiliensis, the rubber particle in the laticiferous vessel is the site of rubber (cis-1-4-polyisoprene) biosynthesis. A 14 kilodalton protein, rubber elongation factor (REF), is associated with the rubber particle in a ratio of one REF to one rubber molecule (Dennis M, Henzel W, Bell J, Kohr W, Light D [1989] J Biol Chem 264: 18618-18628; Dennis M, Light D [1989] J Biol Chem 264: 186...

The prevailing framework for solving referring expression grounding is based on a two-stage process: 1) detecting proposals with an object detector and 2) the referent to one of proposals. Existing solutions mostly focus step, which aims align expressions In this paper, we argue that these methods overlook obvious mismatch between roles in two stages: they generate solely detection confidence (...