Endothelial cell dysfunction (ECD) has been demonstrated in patients with end-stage renal disease (ESRD) who have cardiovascular disease (CD) or diabetes mellitus (DM). While techniques to examine conduit arteries have been adapted to these patients, evaluation of microvascular function has lagged behind. Therefore, we used laser Doppler flowmetry (LDF) and scanned laser Doppler imaging (LDI) t...

The effects of fatigue duration and muscle type on voluntary and evoked contractile properties were investigated with an isometric, intermittent, submaximal fatigue protocol. Four groups performed contractions of the plantar flexors and quadriceps at various intensities to produce long (LDF; 19 min 30 s)- and short-duration fatigue (SDF; 4 min 17 s). The LDF group had a significantly greater de...

OBJECTIVES To test the hypothesis that finger skin vasomotion (FSV), a known factor influencing microvascular blood flow motion, is impaired in SSc patients. Possible relationships between FSV abnormalities and the severity and/or activity of SSc were also investigated. METHODS FSV was investigated by means of spectral Fourier analysis of finger skin laser Doppler flowmetry (LDF) tracing, rec...

Autotransfusion protocols often use the use of costly filters, such as leukocyte-depleting filters (LDFs), to minimize reinfusion of activated leukocytes and inflammatory mediators associated with reperfusion injury (RI). LDFs are used extensively in hospital settings; however, they represent an additional capital expenditure for hospitals, as well as a constraint on the reinfusion rate of bloo...

Haemodynamic changes after smoking two 1.1 mg nicotine cigarettes were monitored in 24 smokers on two different occasions. Smoking caused an increase in heart rate and arterial blood pressure, whereas finger temperature as measured by thermography and finger skin blood flow as measured by laser-Doppler flowmetry (LDF) decreased. Lowest values were seen within 15 min by LDF, and after 30 min by ...

Fisher proposed a linear discriminant function (Fisher’s LDF). From 1971, we analysed electrocardiogram (ECG) data in order to develop the diagnostic logic between normal and abnormal symptoms by Fisher’s LDF and a quadratic discriminant function (QDF). Our four years research was inferior to the decision tree logic developed by the medical doctor. After this experience, we discriminated many d...

Pulse oximetry (PO) and laser-Doppler fluxmetry (LDF) can be used for a determination of tooth vitality by measuring the pulpal blood perfusion. They offer an alternative to conventional sensibility tests, which evaluate only sensory function. The aim study was conduct tests on permanent caries-free carious teeth with different degrees caries progression compare results. In clinical study, 230 ...

25 Vasoactive agents are used in critical care to optimize circulatory function, but their effects on 26 renal tissue oxygenation in the absence of anesthesia remain largely unknown. Therefore, we 27 assessed the effects of multiple vasoactive agents on regional kidney oxygenation in awake 28 sheep. Sheep were surgically instrumented with pulmonary and renal artery flow probes, and 29 combinati...

The cerebral microcirculation consists of a complex network of small blood vessels that support nerve cells with oxygen and nutrition. The blood flow and oxygen delivery in the microcirculatory blood vessels are regulated through mechanisms which may be influenced or impaired by disease or brain damage resulting from conditions such as brain tumors, traumatic brain injury or subarachnoid hemorr...

1. The effects of aminoguanidine (AG) treatment on reductions in motor nerve conduction velocity (MNCV) and sciatic nerve blood flow, indexed by laser Doppler flux (LDF), were investigated in rats with experimental diabetes (streptozotocin-induced; 8-10 weeks duration). The contribution of endoneurial vasoactive nitric oxide to the LDF of these animals was also investigated by the direct micro-...