The samples below are donated by UCSF students, residents and alumni to offer you ideas to format and present your skills and experience. Note: Please do not copy the text verbatim. It is unethical and unwise, as several residency directors recognize our samples. Instead, for extra help, attend on one our monthly Application Materials Clinics or watch our Application Materials Online Workshops ...

The samples below are donated by UCSF students, residents and alumni to offer you ideas to format and present your skills and experience. Note: Please do not copy the text verbatim. It is unethical and unwise, as several residency directors recognize our samples. Instead, for extra help, attend on one our monthly Application Materials Clinics or watch our Application Materials Online Workshops ...

The samples below are donated by UCSF students, residents and alumni to offer you ideas to format and present your skills and experience. Note: Please do not copy the text verbatim. It is unethical and unwise, as several residency directors recognize our samples. Instead, for extra help, attend on one our monthly Application Materials Clinics or watch our Application Materials Online Workshops ...

Despite considerable advances in preventative treatment during the last two decades, the increasing burden of cardiovascular (CV) disease constitutes an urgent need for new therapeutic strategies to reduce CV mortality and morbidity in patients at high CV risk. Activation of the renin-angiotensin system (RAS) results in vasoconstrictive, proliferative and pro-inflammatory effects that contribut...

In the Survival of Myocardial Infarction Long-term Evaluation (SMILE) 1, 3, and 4 studies, early administration of zofenopril in acute myocardial infarction showed to be prognostically beneficial versus placebo or ramipril. The SMILE-2 showed that both zofenopril and lisinopril are safe and showed no significant differences in the incidence of major cardiovascular (CV) complications. In this po...

Nonsteroidal anti-inflammatory drugs (NSAID) have been associated with adverse cardiovascular (CV) outcomes in cancer prevention and other clinical trials. A recent meta-analysis suggested that baseline CV risk is associated with NSAID-associated adverse CV events. We evaluated the effect of baseline CV risk on adverse CV events in a phase III trial of difluoromethylornithine (DFMO) plus the NS...

Coxsackieviruses A10 (CV-A10) and A6 (CV-A6) have been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases and outbreak events globally. However, our understanding of epidemiological and genetic characteristics of these new agents remains far from complete. This study was to explore the circulation of CV-A10 and CV-A6 in HFMD and their genetic characteristics in ...

The effect of lyso-PAF on ciliated cells was investigated in vitro. Normal mucosa was surgically obtained from human paranasal sinuses and incubated in the form of tissue culture. Ciliated epithelium was magnified under an inverted microscope, and ciliary movement was photo-electrically measured. Ciliary activity was significantly inhibited by 10(-8) M lyso-PAF and could be restored. The effect...

The effects of a novel compound, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619), on cerebral and renal vascular changes were examined in stroke-prone spontaneously hypertensive rats (SHRSP) and in rats with experimentally induced hypertension. CV-2619 (35 mg/kg/day, p.o.) significantly inhibited the onset of cerebrovascular lesions (stroke) and the elevation of...

We developed a new climate-sensitive vegetation state-and-transition simulation model (CV-STSM) to simulate future vegetation at a fine spatial grain commensurate with the scales of human land-use decisions, and under the joint influences of changing climate, site productivity, and disturbance. CV-STSM integrates outputs from four different modeling systems. Successional changes in tree species...