INTRODUCTION Plasminogen activator inhibitor 1 (PAI-1) is a key factor in trauma- and sepsis-induced coagulopathy. We examined how trauma-hemorrhage (TH) modulates PAI-1 responses in subsequent cecal ligation and puncture (CLP)-induced sepsis, and the association of PAI-1 with septic outcomes. METHODS Mice underwent TH and CLP 48 h later in three separate experiments. In experiment 1, mice we...

OBJECTIVE Our aim was to determine if the expression pattern of CLP-1 in developing heart is consistent with its role in controlling RNA transcript elongation by transcriptional elongation factor b (P-TEFb) and if the inhibitory control exerted over P-TEFb by CLP-1 is released under hypertrophic conditions. METHODS We performed immunoblot and immunofluorescence analysis of CLP-1 and the P-TEF...

To evaluate the effect of thermocycling on water contact angle (WCA), surface roughness (SR), and microhardness (MH) different CAD-CAM PMMA denture base materials after treatments (conventional laboratory polishing, polishing kit, or sealant). Disk-shaped specimens (10 × 2 mm) 3 PMMAs, AvaDent (AV); Merz M-PM (M-PM); Polident (Poli), a conventional heat-polymerized (Vynacron) (CV) (n=21) were d...

Leukotrienes (LTs) are proinflammatory lipid mediators derived from polyunsaturated arachidonic acid, which is ester-bound at the sn-2 position of glycerol in cellular phospholipid bilayers. In LTs biosynthesis, 5-lipoxygenase (5-LO) represents the key enzyme, which catalyzes two initial steps. The aim of present thesis was to investigate the effects of a small 5-LO binding protein named Coacto...

We tested in B6 mice whether the local expansion of CD4 T cells producing proinflammatory cytokines including IL-17 (Th17 cells) in the colonic lamina propria (cLP) depends on the commensal microflora. High numbers of CD4 Th17 cells were found in the lamina propria of the ileum and colon but not the duodenum, jejunum, mesenteric lymph nodes, spleen, or liver of specific pathogen-free (SPF) mice...

This study aimed to investigate the effects of nonlinear and linear varied practice compared a constant on inhibitory control reaction time, which are capacities that involve cognition in preadolescents. Eighty-three participants 8th grade participated study. They were assigned two experimental groups (varied practice), taught using pedagogy (NLP) (VLP), respectively, or one group (constant (CL...

Non-syndromic (NS) cleft lip (CL) and with palate (CLP) are abnormalities in the orofacial area that not accompanied by head neck have normal physical growth cognitive development. Cleft CLP caused two factors, genetic environmental factors which include deficiencies of micronutrients such as folate vitamin B12. This study aimed to determine differences B12 serum levels between mothers whose ch...

Aim: Cleft lip and palate (CLP) patients have a greater predisposition to tooth malformation, which could affect pulp volume. The aim of this study is evaluate the dental volume central incisors in 3D images between individuals with without CLP. Materials Methods: This retrospective case-control single-centered was recruited January 2016 October 2022. Ninety-four who were followed Institute Ort...

INTRODUCTION The antibacterial effect of ozone (O(3)) has been described in the extant literature, but the role of O(3) therapy in the treatment of certain types of infection remains controversial. OBJECTIVES To evaluate the effect of intraperitoneal (i.p.) O(3) application in a cecal ligation/puncture rat model on interleukins (IL-6, IL-10) and cytokine-induced neutrophil chemoattractant (CI...

The manipulation of CLP(<) programs in CLP(<) is severely limited, since equality for this language is not based on the syntactic structure of terms. We propose an extended language, CLP(< + M), which provides a basis for (a) coding terms in a form which allows arbitrary structural manipulation, and (b) converting between terms and their coded forms. Importantly, CLP(<+ M) may not only be used ...