نتایج جستجو برای: متیلن تتراهیدروفولات ردوکتاز mthfr

تعداد نتایج: 4340  

2017
Sheng Zhang Shuchen Chen Yu Chen Mingqiang Kang Chao Liu Hao Qiu Yafeng Wang Weifeng Tang

The aim of this case-control study was to assess the relationship between the tagging polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene and the susceptibility to colorectal cancer (CRC) in a Chinese Han population. A custom-by-design 48-Plex SNPscan Kit was used to determine the genotypes of MTHFR rs3753584 T>C, rs9651118 T>C, rs1801133 G>A, rs4846048 A>G and rs4845882 G>A polym...

Journal: :Anticancer research 2006
Ali Metin Kafadar Hulya Yilmaz Didem Kafadar Arzu Ergen Umit Zeybek Nilufer Bozkurt Cengiz Kuday Turgay Isbir

BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. A common C677T polymorphism in the gene for MTHFR leads to an enzyme with decreased activity. MTHFR polymorphisms have been studied in various cancers but not in primary brain tumors. The purpose of this case-control study was...

2017
Mildred C. Gonzales Pojui Yu S. Pamela K. Shiao

BACKGROUND The methylenetetrahydrofolate reductase gene (MTHFR) is one of the most investigated genes associated with breast cancer for its role in epigenetic pathways. OBJECTIVES The objectives of this metaprediction study were to examine the polymorphism-mutation risk subtypes of MTHFR and air pollution as contributing factors for breast cancer. METHODS For triangulation purposes in metap...

2015
Xue-bin Wang Chen Qiao Li Wei Ya-di Han Ning-hua Cui Zhu-liang Huang Zu-hua Li Fang Zheng Ming Yan Xu-jie Zhou

Homocysteine (Hcy) is a potential risk factor for age-related cataract (ARC). Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme for Hcy metabolism, and variants of MTHFR may affect MTHFR enzyme activity. This study mainly evaluated the associations between variants in MTHFR gene, plasma MTHFR enzyme activity, total Hcy (tHcy) levels and ARC risk in Chinese population. Four single nu...

Journal: :The hematology journal : the official journal of the European Haematology Association 2001
O Salomon N Rosenberg A Zivelin D M Steinberg N Kornbrot R Dardik A Inbal U Seligsohn

Hyperhomocysteinemia is a defined risk factor for venous thromboembolism (VTE). Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid...

Farsinejad, Alireza, Ala, Fereydoun , Faranoush, Mohammad, Kazemzadeh, Shima, Mohammadi, Rezvan , Shadkam Farokhi, Fatemeh, Shafiian, Alireza,

Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like Glanzmann's t...

Catherine F Hughes, Helene McNulty, JJ Strain, Mary Ward,

Hypertension, defined as a systolic/diastolic blood pressure of 140/90 mmHg or greater, is estimated to carry a three-fold increased risk of developing cardiovascular diseases (CVDs). Evidence from genome-wide association studies has identified an association between blood pressure and the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR). Recent meta-ana...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005
Qiuling Shi Zhendong Zhang Guojun Li Patricia C Pillow Ladia M Hernandez Margaret R Spitz Qingyi Wei

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer. The MTHFR gene has three nonsynonymous single nucleotide polymorphisms (i.e., C677T, A1298C, and G1793A) that have a minor allele frequency of >5%. We investigated the associations betw...

Journal: :Journal of the Korean neurological association 2023

This corrects the article "Neurological Manifestations of MTHFR-related Hyperhomocysteinemia" in volume 41 on page 68.

Journal: :Heart, lung & circulation 2014
Chia-Sheng Chao Jeng Wei Hurng-Wern Huang Shyh-Chyun Yang

BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms are associated with the risk of patent ductus arteriosus (PDA) congenital heart defects. This study aimed to determine the association of these polymorphisms in patients with isolated PDA and in non-PDA patients group without congenital heart disease. METHODS This retrospective case-controlled study was...

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