We demonstrated that the immunological identity of variant peptides may be accurately predicted on the basis of atomic coordination of both unprotonated and protonated tertiary structures, provided that the structure of the native peptide (index) is known. The metric which was discovered to account for this discrimination is the coordination difference between the variant and the index; we also...

Membrane fouling is a major obstacle for ultrafiltration (UF) in water treatment. Here, strategy mitigation, by applying an ultra-low concentration of moderately-hydrophobic chitosan (MHC) and using mildly elevated backwash temperature was proposed. The effects MHC type, concentration, were investigated continuous-flow tests PVDF hollow fiber membranes model raw water. Compared to the process w...

MHC class I (MHC-I) molecules present a blueprint of the intracellular proteome to T cells allowing them control infection or malignant transformation. As response, pathogens and tumor often downmodulate MHC-I mediated antigen presentation escape from immune surveillance. Although fundamental rules are known in detail, players this system not saturated new modules regulation have recently been ...

The objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and beta-adrenergic receptor expression of feedlot heifers during the finishing phase. Heifers (n = 16; initial body weight 457 ± 3 kg) were randomly assigned pens (4 pens/treatment; 2 heads/pen) treatment: (1) no rbST (Control); (2) 500 mg/hd sometribove ...

Functional cognate T cell recognition is mediated via the interaction of a T cell receptor complex with its pMHC ligand. Adams et al. (2011) in this issue of Immunity provide evidence that docking geometry may impact 2D binding and T cell activation.

Background The major histocompatibility complex (MHC) gene family, a vital immune family in vertebrates, helps animals defend against pathogens. polymorphism of MHC genes is important for species and considered to be caused by the numerous alleles antigen-presenting genes. However, mechanism this process unclear due lack data on structure. evolutionary trajectories tetrapod are also because ins...