Zs. Podolyák, S. Al-Garni, R.F. Casten, J.R Cooper,* D.M. Cullen, A. Dewald, R. Krücken, H. Newman, J.N. Orce, C.J. Pearson, C. Ur, R. Venturelli, S. Vincent, C. Wheldon, P.M. Walker, F.R. Xu, A. Yamamoto, and N.V. Zamfir Department of Physics, University of Surrey, Guildford GU2 7XH, United Kingdom A.W. Wright Nuclear Structure Laboratory, Department of Physics, Yale University, New Haven, Con...

Small non‑coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation and progression. In the present study, the expression level of miR‑181 was reduced in glioma tissues c...

MiR-181 was highly expressed in lung cancer cells of cisplatin-resistance. In this study, we sought to explore the connection of miR-181 expression with cell proliferation, invasion and apoptosis in cervical cancer cells. Real-time polymerase chain reaction and Western blot were performed to determine the expression level of miR181 at mRNA and protein level. Then MTT and flow cytometry were res...

http://bmj.com/cgi/content/full/333/7560/181 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/333/7560/181#BIBL This article cites 24 articles, 6 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/333/7560/181 You can respond to this article at: http://bmj.com/cgi/content/full/333/7560/181#responses free...

Dysregulated expression of microRNAs (miRNAs) has been observed in numerous types of human cancer, including cervical cancer (CC). The present study aimed to elucidate the expression and roles of miR‑181 in cervical cancer tissues and cells. HeLa cells with a stable overexpression of miR‑181 were generated and injected subcutaneously into the front legs of nude mice. Functional assays revealed ...

To the Editor: Nordmann et al. (1) raised concern over the global spread of carbapenemase-producing Enterobacteriaceae. In their article, they called attention to the oxacillinase-48 (OXA-48) type carbapenemases because bacteria that produce these enzymes do not have a distinctive antimicrobial drug susceptibility profi le, and there is less awareness of this mechanism of carbapenem resistance....

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Objective: To investigate the prevalence of traumatic events and life events in relation to posttraumatic stress disorder (PTSD). Method: In a Danish national representative sample of 390 eighth-grade students with a mean age of 14.5 years, 20 prevalent potential traumatizing and distressing events were described, along with the psychological impact of these events. Results: Eighty-seven percen...

A number of miRNAs have been found to be abnormally expressed or mutated in numerous cancers and thus, are considered to act as oncogenes or tumor suppressor genes. The aim of the present study was to investigate the effect of miR-181 on cisplatin-resistant non-small cell lung cancer (NSCLC). In patients with cisplatin-resistant NSCLC, miR-181 expression was found to be markedly decreased. In a...

Accumulating evidence has indicated that microRNA-181 (miR-181) is dysregulated in hematological malignancies, and associates with the clinical outcomes. However, the association of miR-181 expression levels with acute myeloid leukemia (AML) remains inconclusive, as publications from different groups have reported contradictory results. In this manuscript, a meta-analysis was performed to asses...