نتایج جستجو برای: فاکتور رونویسی creb1
تعداد نتایج: 14730 فیلتر نتایج به سال:
بیماری برونشیت عفونی یکی از بیماری‌های ویروسی بسیار عفونی و شایع طیور می‌باشد. در این مطالعه به منظور درک بهتر شبکه تنظیمی درگیر در بیماری برونشیت عفونی، در ابتدا ژن های با بیان بالا و مشابه با استفاده از تجزیه و تحلیل داده‌های یک مطالعه RNA-Seq در چهار حالت متفاوت شامل مقایسه‌ی بافت طحال جوجه‌های مبتلا به برونشیت با جوجه‌های سالم با غلظت پایین سرم مانوز باند شده با لکتین در سن یک هفتگی و سه هف...
in this study, several designed creb1-specific shrnas cloned into lentiviral transfer vectors were screened in293t by transient transfection assays. relative creb1 expression was determined by relative qrt-pcr. all of the designed shrnas gave some level of knockdown. one shrna was more effective for knocking down the specific gene among others. the predicted sirnas activities as determined by r...
Excitatory and inhibitory inputs converge on single neurons and are integrated into a coherent output. Although much is known about short-term integration, little is known about how neurons sum opposing signals for long-term synaptic plasticity and memory storage. In Aplysia, we find that when a sensory neuron simultaneously receives inputs from the facilitatory transmitter 5-HT at one set of s...
MicroRNAs (miRNAs) act as key regulators of multiple cancers. MicroRNA-506 (miR-506) functions as a tumor suppressor in various types of cancers. However, its role in esophageal cancer remains unclear. In our study, we found that miR-506 was significantly down-regulated in esophageal cancer tissues and cell lines. In vitro assay, our results showed that ectopic over-expression of miR-506 inhibi...
زمینه مطالعه: لاکتوفرین، گلیکوپروتیین متصل شونده به آهن، دارای نقش‌های فیزیولوژیکی متعددی می باشد که مهمترین آنها خواص آنتی میکروبی است. از این رو ژن کد کننده این پروتیین می تواند به عنوان ژن کاندیدایی در مقاومت به بیماری ورم پستان در نظر گرفته شود. هدف: بررسی ناحیه َ5 ژن لاکتوفرین گاو در نمونه‌های بومی و هلشتاین با استفاده از روش PCR-SSCP و تعیین توالی می باشد. روش کار: برای این منظور از تعدا...
CONTEXT Previous functional neuroimaging studies have identified a network of brain regions that process aversive stimuli, including anger. A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men wit...
Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in vivo functions and molecular mechanism of UCA1 in CRC remain unclear. Therefore, we investigated the detailed role and mechanism of UCA1 in CRC. We found that UCA1 was up-regulated in CRCs and negatively correlated w...
BACKGROUND In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology and both the mutant gene and the protein are found in cells and tissues throughout the body. Despite the adipose tissue gene expression alterations described in HD mouse models, adipose tissue and its gene expression signature have not been previously explored in human HD....
To achieve proper spatiotemporal control of gene expression, transcription factors cooperatively assemble onto specific DNA sequences. The ETS domain protein monomer of GABPα and the B-ZIP domain protein dimer of CREB1 cooperatively bind DNA only when the ETS ((C)/GCGGAA GT: ) and CRE ( GT: GACGTCAC) motifs overlap precisely, producing the ETS↔CRE motif ((C)/GCGGAA GT: GACGTCAC). We designed a ...
Lysosomal-associated protein transmembrane-4 beta (LAPTM4B) is a potential proto-oncogene, whose overexpression is involved in cancer occurrence and progression. Its transcript is up-regulated in various types of solid tumors including breast cancer. However, its transcriptional regulation mechanism is still unclear. To investigate the mechanism of transcriptional regulation of LAPTM4B in human...
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