AIM To investigate the feasibility of placing a screw in the C2 lamina and evaluate the reliability of the surface of the dorsal arch of C2 as a landmark for determining the optimal site of screw entry. MATERIAL AND METHODS 88 adult human C2 spines were used. Seven measurements were determined for screw entry points, trajectories, and lengths for placement of intralaminar screws. RESULTS Th...

BACKGROUND Positive spinal regional and global sagittal malalignment has been repeatedly shown to correlate with pain and disability in thoracolumbar fusion. OBJECTIVE To evaluate the relationship between regional cervical sagittal alignment and postoperative outcomes for patients receiving multilevel cervical posterior fusion. METHODS From 2006 to 2010, 113 patients received multilevel pos...

It is proved that each group of order 32 that has a maximal subgroup isomorphic to C2×C2×C2×C2 or C4×C4 is determined by its endomorphism semigroup in the class of all groups.

Definition. A couple of complex reduced projective plane curves C1 and C2 of a same degree is said to make a Zariski pair, if there exist tubular neighborhoods T (Ci) ⊂ P of Ci for i = 1, 2 such that (T (C1), C1) and (T (C2), C2) are diffeomorphic, while the pairs (P, C1) and (P , C2) are not homeomorphic; that is, the singularities of C1 and C2 are topologically equivalent, but the embeddings ...

A vast amount of protein sequence data accumulated over recent years has revealed that protein modules are widespread in nature. Many intracellular and extracellular proteins consist, in part or fully, of combinations of protein modules. C2-domains, together with SH2, PTB, PH, SH3, WW, and PDZ domains, are typical examples of intracellular protein modules. These modules form independently foldi...

Ceramide, formed by sphingomyelinase, is involved in the expression of cyclooxygenase-2 (COX-2). This study examines the effect of C2-ceramide (C2), a cell-permeable ceramide analog, on the lipopolysaccharide (LPS)-inducible COX-2 expression and signaling pathways. C2 did not induce COX-2 but potentiated LPS-inducible COX-2 expression in Raw264.7 cells, whereas dihydro-C2 was inactive. Treatmen...

AIMS AND OBJECTIVES The alignment of upper and lower cervical spine is presumed to be closely interrelated and the knowledge of this is mandatory when performing occipito-cervical and upper cervical fusions. The aim of this study was to establish standard values for upper and lower cervical spine alignment in the Indian population. MATERIALS AND METHODS Five hundred eighteen asymptomatic volu...

C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-...