Recent advances in stem cell research have resulted in methods to generate kidney organoids from human pluripotent stem cells (hPSCs), which contain cells of multiple lineages including nephron epithelial cells. Methods to purify specific types of cells from differentiated hPSCs, however, have not been established well. For bioengineering, cell transplantation, and disease modeling, it would be...

background: kinesin spindle protein (ksp) plays a critical role in mitosis. inhibition of ksp function leads to cell cycle arrest at mitosis and ultimately to cell death. the aim of this study was to suppress ksp expression by specific small-interfering rna (sirna) in hep3b cells and evaluate its anti-tumor activity. methods: three sirna targeting ksp (ksp-sirna #1-3) and one mismatched-sirna (...

the solubility of k2so4 in water at 25°c was determined. comparing the value ofthermodynamic solubility product constant, ksp(th), (ksp(th) = exp (-δgodiss rt) of the mentionedsalt to the value of concentration solubility product, ksp(c) which is obtained from the observedsolubility, s/mol-1, ksp(c) = 4s3, revealed a great difference. the difference can be satisfactorilyexplained using debye- h...

BACKGROUND Transcription factor Nrf2 protects from experimental acute kidney injury (AKI) and is promising to limit progression in human chronic kidney disease (CKD) by upregulating multiple antioxidant genes. We recently demonstrated that deletion of Keap1, the endogenous inhibitor of Nrf2, in T lymphocytes significantly protects from AKI. In this study, we investigated the effect of Keap1 del...

The potential for Ksp-cadherin involvement in either the development or maintenance of the metanephric kidney was assessed by immunocytochemical localization of a monoclonal antibody directed against the rabbit isoform of Ksp-cadherin in both neonatal and adult rabbit kidneys. In the adult kidney Ksp-cadherin expression was detected on the basolateral membrane of all cell types in both the tubu...

In this study, the ion association phenomenon in the saturated solution of KCl in the mixed solvent(methanol+water) was studied. The solubility of this compound in the mixed solvent (methanol+water by value percent of methanol = 60%), and in the presence of various molarities of NaNO3 wasdetermined by the solvent evaporation method at 25.0°C. The results enable us to estimate the valueof thermo...

اهتفاقثو اهرخفو ةملأا ةيأ ةيوه نم أزجتي لا اءزج يرامعملا ثارتلا لكشي . ةيخيراتلا ةرامعلا رصانع نا يف اهؤانبو اهميمصت مت دق ةيملاسلإا تابلطتمل يويحو لاعف لكشب ةباجتسلاا ىلع ةرداق نوكت ثيحب يضاملا ةينيدلاو ةيسفنلاو ةيعامتجلااو ةيئيبلاو ةيداملا سانلا . رضاحلا تقولا يف نويرامعملا نوسدنهملا موقي رصانعلا ذخأب اوذخأي ام ةداعو ميمصتلا عيراشم يف اهلاخدا و ةيملاسلإا ةيخيراتلا ينابملا نم ةفلتخملا نيوكت ر...

طوفان‌های گردوغبار بلایایی طبیعی‌اند که در زندگی انسان و محیط‌زیست تأثیر چشمگیری گذاشته‌اند. توسعة مدل‌هایی، به‌منظور پیش‌بینی مسیر حرکت این طوفان‌ها، پیشگیری مدیریت نقش بسزایی ایفا می‌کند زیرا انتقال آنها را آشکار مناطق آسیب‌پذیر بعدی برابر طوفان مشخص می‌کنند. به‌لطف امکانات روش‌های یادگیری عمیق حل مسائل مبتنی‌بر سری زمانی یافتن الگوهای پنهان از حجم دادة کلان، پژوهش، یک مدل ترکیبی شبکة عصبی پی...

یکی از مهم‌ترین مدهای حمل‌ونقل عمومی شبکة مترو است که تأثیر بسزایی در کاهش ترافیک و آلودگی هوا دارد. ازدیگرسو، با توجه به هزینه‌های سرسام‌آور راه‌اندازی مترو، توسعة مرحله‌به‌مرحله بهره‌برداری یک خط اجرای خطوط دیگر به‌دست مدیران شهری مورد است. بنابراین، هدف این تحقیق بررسی میزان دسترسی متروی اصفهان افق 1410، رویکرد عدالت مکانی، دو جنبة افقی عمودی پنج طبقة اجتماعی، استفاده شاخص‌های ضریب جینی، منح...

This research was carried out to evaluate the capability of a combined fuzzy logic-based approach and analytical hierarchy process (AHP) for potassium saturation percentage (KSP) estimation in some calcareous soils of southern Iran. Based on a reconnaissance soil survey, 52 soil series were selected and different physical and chemical properties were determined. Five soil parameters including c...