BACKGROUND AND PURPOSE Cerebral microbleeds are thought to have potentially important clinical implications in dementia and stroke. However, the use of both T2* and SWI MR imaging sequences for microbleed detection has complicated the cross-comparison of study results. We aimed to determine the impact of microbleed sequences on microbleed detection and associated clinical parameters. MATERIAL...

A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate, and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes including gene expression, nuclear organization, centromere function, and chromosomal stability, and m...

SWI-Prolog is a Prolog implementation based on a subset of the WAM (Warren Abstract Machine). SWI-Prolog was developed as an open Prolog environment, providing a powerful and bi-directional interface to C in an era this was unknown to other Prolog implementations. This environment is required to deal with XPCE, an object-oriented GUI system developed at SWI. XPCE is used at SWI for the developm...

1. Abstract 2. Introduction 2.1. Histone acetyltransferase and deacetylase complexes 2.2. SWI/SNF family of chromatin remodeling complexes 3. Activator targeting of histone acetyltransferase complexes 4. Activator targeting of SWI/SNF complexes 5. Communication between HATs and SWI/SNF at promoter nucleosomes 6. Repressor targeting of histone deacetylase complexes 7. Perspectives 8. Acknowledge...

Findings on Susceptibility-Weighted Imaging Developmental venous anomaly (DVA) is the most common type of vascular malformation found at autopsy, with a prevalence of 2%. DVA is composed of radially arranged venous complexes converging to a centrally located venous trunk, which drains the normal brain parenchyma. Susceptibility-weighted imaging (SWI) shows low signal intensity for DVA due to th...

BACKGROUND AND PURPOSE Asymmetric hypointensity of cerebral veins on susceptibility-weighted imaging has been shown to indirectly reflect tissue hypoxia after cerebral ischemia. We therefore investigated whether patients with prominent asymmetry of the cerebral veins on SWI and a relatively small diffusion-weighted imaging lesion (SWI-DWI mismatch), representing the presence of salvageable tiss...

OBJECTIVE The aim of this study was to investigate variant patterns of cortical venous oxygenation during status epilepticus (SE) using susceptibility-weighted imaging (SWI). METHODS We analyzed magnetic resonance imaging (MRI) scans of 26 patients with clinically witnessed prolonged seizures and/or EEG-confirmed SE. All MRI exams encompassed SWI, dynamic susceptibility contrast perfusion MRI...

BACKGROUND AND PURPOSE Susceptibility-weighted imaging (SWI) has been shown to be more sensitive in detecting cerebral microbleeds (MBs) than is conventional T2*-weighted gradient-recalled echo imaging (GRE). However, the clinical relevance of this improved detection in terms of associations with clinical measures and risk factors is unclear. We sought to determine whether associations of MBs w...

OBJECTIVE To provide a comprehensive and latest overview of susceptibility-weighted imaging (SWI) in the application of thrombolysis in acute ischemic stroke, and to update the decision-making effect and clinical value of SWI on identifying stroke patients suitable for thrombolytic therapy and possible benefits and risks followed. DATA SOURCES Literatures referred to this review were collecte...

OBJECTIVE To present a detailed explanation on the processing of magnetic susceptibility weighted imaging (SWI), demonstrating the effects of echo time and sensitive mask on the differentiation between calcification and hemosiderin. MATERIALS AND METHODS Computed tomography and magnetic resonance (magnitude and phase) images of six patients (age range 41- 54 years; four men) were retrospectiv...