We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation. Treatment of cells with CAPE (2.5 mg/ml) suppressed phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) and calcium ionophore (A23187)-mediated in...

Examination of the helminth communities in 25 yellow-billed ducks (Anas undulata), 21 red-billed ducks (Anas erythrorhyncha), ten Cape teal (Anas capensis) and seven Cape shovellers (Anas smithii) that had overwintered at Barberspan, revealed differences in community structure. Infracommunities in yellow-billed and red-billed ducks were characterized by low diversity and high eveness, and gener...

1​ Gene Expression & Biophysics Group, CSIR Synthetic Biology ERA, Pretoria, 0001, South Africa. 2​ Institute of Infectious Diseases & Molecular Medicine (IDM), Division of Chemical Systems & Synthetic Biology, University of Cape Town, Cape Town, 7925, South Africa. 3​ KwaZulu-Natal Research Institute for TB-HIV (K-RITH), Durban, 4001, South Africa. 4​ University of KwaZulu-Natal, Durban, 404...

D. A. Auger, X. zhong, E. Meintjes, F. Epstein, and B. Spottiswoode MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, Western Cape, South Africa, MR R&D Collaborations, Siemens Medical Solutions, Atlanta, GA, United States, 3Departments of Radiology and Biomedical Engineering, University of Virginia, Charlottesville VA, United States, Radiology, University of Stellenbos...

1t d reid, 2H Ipp, 3L Becker, 1R H Glashoff. 1Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; 2Division of Haematology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University & NHLS, Cape Town, South Africa; 3Desmond Tutu Foundation for HIV Research, University of...

Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities. However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated. In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells. Results...

1 Genital Mucosal HIV and STI Research Group, Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Medical Virology Laboratory, Cape Town, South Africa, 2 Genital Mucosal HIV and STI Research Group, Department of Pathology, Division of Medical Virology, NRF-DST CAPRISA CENTRE OF EXCELENCE, University of Cape Town, Cape Town, South Africa, 3...

Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cell...

2015 Vol 7 No 1 South Afr J Gynaecol Oncol Elhassan MMA,1 FCRadOnc, MMedRadOnc, Radiation Oncologist Wu H-T,2 FCPathAnat, MMed, Senior Consultant Van Wijk AL,3 FFRAD(T), Senior Consultant Radiation Oncology Department, National Cancer Institute, University of Gezira, Wad Madani, Sudan Department of Anatomical Pathology, University of Cape Town, Cape Town National Health Laboratory Service, Groo...

CATHERINE PITT*, ANNA VASSALL, YOT TEERAWATTANANON, ULLA K. GRIFFITHS, LORNA GUINNESS, DAMIAN WALKER, NICOLA FOSTER and KARA HANSON Department of Global Health & Development, London School of Hygiene & Tropical Medicine, London, UK Health Intervention and Technology Assessment Program, Ministry of Health, Bangkok, Thailand The Bill & Melinda Gates Foundation, Seattle, USA Health Economics Unit,...