Hepatocellular carcinoma (HCC) is third in cancer-related causes of death worldwide and its treatment is a significant unmet medical need. Sunitinib is a selective tyrosine kinase inhibitor of the angiogenic biomarker: soluble vascular endothelial growth factor receptor-2 (sVEGFR2 ). Sunitinib failed its primary overall survival endpoint in patients with advanced HCC in a phase III trial compar...

Although apolipoprotein with molecular weight 14 kDa (apo-14 kDa) is associated with fish plasma high-density lipoproteins (HDLs), it remains to be determined whether apo-14 kDa is the homologue of mammalian apoA-II. We have obtained the full cDNA sequences that encode Japanese eel and rainbow trout apo-14 kDa. Homologues of Japanese eel apo-14 kDa sequence could be found in 14 fish species dep...

The 'tongue-and-groove problem' in step-and-shoot delivery of intensity modulated radiotherapy is investigated. A 'tongue-and-groove' index (TGI) is introduced to quantify the 'tongue-and-groove' effect in step-and-shoot delivery. Four different types of leaf sequencing methods are compared. The sliding window method and the reducing level method use the same number of field segments to deliver...

O câncer é a segunda principal causa de morte no mundo, atrás somente das doenças cardiovasculares. Nos EUA, foram estimadas cerca 153.000 e mais 169.000 mortes por cânceres do trato gastrointestinal (TGI) para os anos 2016 2021, respectivamente, enquanto Brasil houve 81.000 óbitos pelo mesmo tipo em 2021. Porém, escassa literatura referente estimativas interior Goiás. Assim, o objetivo deste t...

BACKGROUND Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with (18)F-misonidazole ([18F]-FMISO, a probe that detects hypoxia) PET, in response to window-of-opportunity (WoO) treatment with th...

Patients with gastrointestinal cancer and malnutrition are less likely to tolerate major surgical procedures, radiotherapy or chemotherapy. In general, they display a higher incidence of complications such as infection, dehiscence and sepsis, which increases the length of stay and risk of death, and reduces quality of life. The aim of this review is to discuss the pros and cons of different poi...

PURPOSE PP2A is a serine/threonine phosphatase critical to physiological processes, including apoptosis. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage. Our goal was to develop cell-penetrating fusion peptides specifically designed to disrupt the caspase-9/PP2A interaction and evaluate their therapeutic potential in vitro and in vivo. E...

PURPOSE Aurora A and B are oncogenic serine/threonine kinases that regulate mitosis. Overexpression of Auroras promotes resistance to microtubule-targeted agents. We investigated mechanistic synergy by inhibiting the mitotic spindle apparatus in the presence of MLN8237 [M], an Aurora A inhibitor with either vincristine [MV] or docetaxel [MD] in aggressive B-cell non-Hodgkin lymphoma (B-NHL). Th...

Understanding paleoenvironmental conditions of the permafrost formation allows us to estimate carbon pool and its behavior upon thawing in a changing climate. In order classify different types ground ice reconstruct paleoenvironments, we examined geochemical data wedges (IWs), tabular (TGI), lens from eastern coast Faddeevsky Peninsula (East Siberian Arctic). We analyzed isotope ion composition...

El soporte nutricional es de suma importancia en la cirugía digestiva, debido a que se interviene el tracto gastrointestinal (TGI) asegura digestión y reabsorción los alimentos. intestino delgado principal receptor absorción cuando está sano garantiza mayor parte macronutrientes ingeridos, siempre mezcle con jugo pancreato-duodenal contiene las enzimas exocrinas. La porción sana del TGI indicar...