OBJECTIVE To explore the effects of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain (CNP) and spinal microglia in a rat model of chronic constriction injury (CCI). METHODS Male SD rats were assigned into control, sham, CCI, wortmannin, dimethyl sulfoxide (DMSO) and wortmannin-positive control groups. Paw withdrawal mechanical threshold (PWMT) and thermal withdrawal late...

INTRODUCTION Effect of bariatric surgery on health-related quality of life (HRQOL) varies greatly. This might be caused by the diversity in questionnaires used to assess HRQOL and the weight loss of the studied population. This study assesses the relationship between weight loss and HRQOL in primary Roux-en-Y gastric bypass (RYGB) patients by using an obesity-specific (impact of weight on quali...

Background and aims Bariatric Surgery (BS) is a therapeutic option in patients with severe obesity whose non-surgical techniques have failed. No work has previously explored trajectories of weight loss how long this was maintained. Aim study to describe effect BS nutritional intervention on body trend obesity. Methods 792 who underwent from 1996 2021 were included. The Protocol provides Laparos...

In the original article Figs. 1 and 2 are incomplete. The data tables including EBMIL, TWL n should have accompanied both Fig. 2. corrected figures follow.

Background: Protein intake and physical activity have a substantial impact on body composition weight loss outcomes after bariatric surgery. The 24-h dietary recall 6-min walk test (6mWT) are frequently used to monitor protein activity, respectively. Despite its frequent use, it is unknown whether these tests can predict long-term loss. Methods: This retrospective study included 85 patients who...

Objective. Compare the effectiveness of systemic and local administration adipose-derived mesenchymal stem cells (ADMSC) at a dose 1х106 cells/kg on nociceptive sensitivity to mechanical thermal stimuli in rats changes histostructure sciatic nerve surrounded tissues affected hind paw experimental model peripheral neuropathy nerve. Materials methods. 26 male Wistar were used perform by axotomy O...