Human proteinase inhibitor 9 (PI-9/serpinB9) and the murine ortholog, serine proteinase inhibitor 6 (SPI-6/serpinb9) are members of a family of intracellular serine proteinase inhibitors (serpins). PI-9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protects these cells against the actions of granzyme B, and when expressed in tumor cells or virally infected hepatocytes, confers...

Meteorological drought monitoring is important for drought early warning and disaster prevention. Regional meteorological drought can be evaluated and analyzed with standardized precipitation index (SPI). Two main processing schemes are frequently adopted: (1) mean of all SPI calculated from precipitation at individual stations (SPI-mean); and (2) SPI calculated from all-station averaged precip...

Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regula...

SUMMARY Structured approaches are beneficial for successful software process improvement (SPI). However, process engineers often struggle with standardized SPI methods, such as CMMI or ISO 15504, and complain about too generic or voluminous approaches, or methods that are alien to the organizations in which SPI is conducted. Therefore, process engineers need to customize existing SPI models or ...

Tumors have several mechanisms to escape from the immune system. One of these involves expression of intracellular anticytotoxic proteins that modulate the execution of cell death. Previously, we have shown that the serine protease inhibitor (serpin) SPI-6, which inactivates the cytotoxic protease granzyme B (GrB), is capable of preventing cytotoxic T lymphocyte (CTL)-mediated apoptosis. Despit...

Offspring of female rats fed either a casein (CAS) diet or a low-isoflavone soy protein isolate (SPI) diet were compared in an animal model of chronic ethanol consumption to investigate whether maternal diet regulates the adaptive responses of offspring to postnatal ethanol exposure and potentially affects the development of liver disease in later life. Female rats were fed either a CAS or an S...

Ectromelia virus (ECTV) is a natural pathogen of mice that causes mousepox, and many of its genes have been implicated in the modulation of host immune responses. Serine protease inhibitor 2 (SPI-2) is one of these putative ECTV host response modifier proteins. SPI-2 is conserved across orthopoxviruses, but results defining its mechanism of action and in vivo function are lacking or contradicto...

OBJECTIVE: Spiral Projection Imaging (SPI) is a versatile, fast 3D data acquisition. Data are sampled on 2D spiral planes that are rotated to fill a sphere in k-space (figure 1). The spiral basis of SPI provides flow insensitivity. Furthermore, it has been shown that SPI allows for six degrees of motion correction similar to that used in PROPELLER. SPI requires far fewer excitations than a line...

Spi-B and PU.1 are hematopoietic-specific transcription factors that constitute a subfamily of the Ets family of DNA-binding proteins. Here we show that contrary to previous reports, PU.1 and Spi-B have very different expression patterns. PU.1 is expressed at high levels in B cells, mast cells, megakaryocytes, macrophages, neutrophils, and immature erythroid cells and at lower levels in mature ...

We introduce the spi calculus, an extension of the pi calculus designed for describing and analyzing cryptographic protocols. We show how to use the spi calculus, particularly for studying authentication protocols. The pi calculus (without extension) suffices for some abstract protocols; the spi calculus enables us to consider cryptographic issues in more detail. We represent protocols as proce...