Cytokeratins CK 8 and CK 18 are the two keratins expressed in the liver. They are known to undergo extensive changes in expression with alteration of the hepatocyte phenotype in vitro. In this study, we have investigated the variation in levels of these two cytokeratins in hepatocytes selected from different situations in vivo. The amounts of corresponding transcripts were compared; cytokeratin...

BACKGROUND In a previous study, the authors used a variety of anticytokeratin monoclonal antibodies to show that a large proportion of lung tumors cytologically diagnosed as squamous cell carcinoma contain cells expressing simple epithelial cytokeratins, suggesting that these tumors have their origin in adenocarcinoma. These findings raised the possibility that cytokeratin (CK) typing might hav...

The author reports a very rare case of spindle cell carcinoma (SpCC) of the urinary bladder progressed from ordinary papillary transitional cell carcinoma (TCC). A 63-year-old man complained of hematuria. A transurethral endoscopic examination revealed a papillary tumor, and transuthetral resection of bladder tumor (TUR-BT) was performed and was diagnosed as ordinary papillary urothelial TCC. S...

The objective of the present study was to establish role sarcomeric mitochondrial creatine kinase (Mt-CK) in muscle energy output during exercise a murine model ageing (the Mt-CK knock-out mouse, Mt-CK?/?). Three age groups Mt-CK?/? mice and control male (6, 9, 18 months age) underwent incremental treadmill running tests. maximum speed (Vpeak) maximal oxygen consumption (VO2peak) values were re...

We compared the usefulness of four serum assays for classifying patients originally suspected of having an acute myocardial infarction. One of these is the long-used measurement of total creatine kinase (CK) activity. The other three are relatively new immunoassays: myoglobin by RIA, CK-BB by RIA, and CK-MB by immunoinhibition. When we evaluated test effectiveness with use of conventionally der...

1269 7 135 ± 13 1510 6 164 ± 17 1920 5 320 ± 35 We recently observed a serum showing a definite LDH 6 band with an increase in CK-BB. The patient, a 77year-old man, had suffered a concussion. The serum was sent to us from the hospital to which he had beeh admitted. Serum total CK was 368 U/L (normal 0-178). Total LDH 2010 U/L (normal 100-225). Cellulose acetate electrophoresis (Helena system) t...